Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review
Salicylic acid (SA) derivate is well-known for its anti-inflammatory and analgesic activity through cyclooxygenase (COX)-inhibition. Previous studies pointed toward gastric toxicity induced by most salicylic acid derivative compounds, particularly acetylsalicylic acid (ASA). Despite the adverse effe...
| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
American Chemical Society
2022
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| Acesso em linha: | https://repository.ugm.ac.id/283425/1/53_Synthesis%2C%20Characterization%2C%20and%20Application%20of%202-%28%283-%28Chloromethyl%29-benzoyl%29oxy%29benzoic%20Acid%20A%20Review.pdf |
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| author | Tjahjono, Yudy Caroline, Caroline Foe, Kuncoro Karnati, Srikanth Ergün, Süleyman Esar, Senny Yesery Wijaya, Hendy Hadinugroho, Wuryanto Kusindarta, Dwi Liliek Wihadmadyatami, Hevi |
| author_facet | Tjahjono, Yudy Caroline, Caroline Foe, Kuncoro Karnati, Srikanth Ergün, Süleyman Esar, Senny Yesery Wijaya, Hendy Hadinugroho, Wuryanto Kusindarta, Dwi Liliek Wihadmadyatami, Hevi |
| author_sort | Tjahjono, Yudy |
| collection | UGM |
| description | Salicylic acid (SA) derivate is well-known for its anti-inflammatory and analgesic activity through cyclooxygenase (COX)-inhibition. Previous studies pointed toward gastric toxicity induced by most salicylic acid derivative compounds, particularly acetylsalicylic acid (ASA). Despite the adverse effect, ASA is still used due to price affordability and additional advantages in preventing platelet aggregation. Recently, a novel salicylic acid derivative called 2-((3 (chloromethyl)benzoyl)oxy)benzoic acid (3-CH2Cl) was introduced as a potential alternative compound to substitute ASA. Preliminary assessment results of COX-2 specificity, toxicity profile, analgesic, anti-inflammatory, and antiplatelet activity have made 3-CH2Cl a promising compound for "new"drug development. This review focuses on the discovery, potential activity, and benefits of 3-CH2Cl and the possible molecular mechanisms of its regulations in health and disease. Thus, this review may prove to be beneficial for the utilization of 3-CH2Cl as a potential alternative drug to substitute ASA. © 2022 The Authors. Published by American Chemical Society. |
| first_indexed | 2024-03-14T00:07:49Z |
| format | Article |
| id | oai:generic.eprints.org:283425 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:07:49Z |
| publishDate | 2022 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2834252023-11-21T03:13:36Z https://repository.ugm.ac.id/283425/ Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review Tjahjono, Yudy Caroline, Caroline Foe, Kuncoro Karnati, Srikanth Ergün, Süleyman Esar, Senny Yesery Wijaya, Hendy Hadinugroho, Wuryanto Kusindarta, Dwi Liliek Wihadmadyatami, Hevi Analytical Chemistry Salicylic acid (SA) derivate is well-known for its anti-inflammatory and analgesic activity through cyclooxygenase (COX)-inhibition. Previous studies pointed toward gastric toxicity induced by most salicylic acid derivative compounds, particularly acetylsalicylic acid (ASA). Despite the adverse effect, ASA is still used due to price affordability and additional advantages in preventing platelet aggregation. Recently, a novel salicylic acid derivative called 2-((3 (chloromethyl)benzoyl)oxy)benzoic acid (3-CH2Cl) was introduced as a potential alternative compound to substitute ASA. Preliminary assessment results of COX-2 specificity, toxicity profile, analgesic, anti-inflammatory, and antiplatelet activity have made 3-CH2Cl a promising compound for "new"drug development. This review focuses on the discovery, potential activity, and benefits of 3-CH2Cl and the possible molecular mechanisms of its regulations in health and disease. Thus, this review may prove to be beneficial for the utilization of 3-CH2Cl as a potential alternative drug to substitute ASA. © 2022 The Authors. Published by American Chemical Society. American Chemical Society 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283425/1/53_Synthesis%2C%20Characterization%2C%20and%20Application%20of%202-%28%283-%28Chloromethyl%29-benzoyl%29oxy%29benzoic%20Acid%20A%20Review.pdf Tjahjono, Yudy and Caroline, Caroline and Foe, Kuncoro and Karnati, Srikanth and Ergün, Süleyman and Esar, Senny Yesery and Wijaya, Hendy and Hadinugroho, Wuryanto and Kusindarta, Dwi Liliek and Wihadmadyatami, Hevi (2022) Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review. ACS Omega. ISSN 24701343 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145592414&doi=10.1021%2facsomega.2c05566&partnerID=40&md5=6b62316b2fe167b307426567523bebed |
| spellingShingle | Analytical Chemistry Tjahjono, Yudy Caroline, Caroline Foe, Kuncoro Karnati, Srikanth Ergün, Süleyman Esar, Senny Yesery Wijaya, Hendy Hadinugroho, Wuryanto Kusindarta, Dwi Liliek Wihadmadyatami, Hevi Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review |
| title | Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review |
| title_full | Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review |
| title_fullStr | Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review |
| title_full_unstemmed | Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review |
| title_short | Synthesis, Characterization, and Application of 2-((3-(Chloromethyl)-benzoyl)oxy)benzoic Acid: A Review |
| title_sort | synthesis characterization and application of 2 3 chloromethyl benzoyl oxy benzoic acid a review |
| topic | Analytical Chemistry |
| url | https://repository.ugm.ac.id/283425/1/53_Synthesis%2C%20Characterization%2C%20and%20Application%20of%202-%28%283-%28Chloromethyl%29-benzoyl%29oxy%29benzoic%20Acid%20A%20Review.pdf |
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