Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines
One of the characteristics of cancer cells is uncontrolled proliferation. This can be caused by aberrant in the proteins that play a role in the process of apoptosis and cell cycle. Lamesticumin A and 2-ethyl,3-(1’-hydroxy-2’-menthene) propenal have been isolated from ethyl acetate extract of L. dom...
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| Format: | Article |
| Language: | English |
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Society for Indonesian Biodiversity
2022
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| Online Access: | https://repository.ugm.ac.id/283617/1/45_Short%20Communication%20Terpenoids%20isolated%20from%20Lansium%20domesticum%20fruit%20peel%20induce%20apoptosis%20and%20cell%20cycle%20arrest%20in%20T-47D%20cell%20lines.pdf |
| _version_ | 1797037708302876672 |
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| author | Fadhilah, Khusnul Wahyuono, Subagus Astuti, Puji |
| author_facet | Fadhilah, Khusnul Wahyuono, Subagus Astuti, Puji |
| author_sort | Fadhilah, Khusnul |
| collection | UGM |
| description | One of the characteristics of cancer cells is uncontrolled proliferation. This can be caused by aberrant in the proteins that play a role in the process of apoptosis and cell cycle. Lamesticumin A and 2-ethyl,3-(1’-hydroxy-2’-menthene) propenal have been isolated from ethyl acetate extract of L. domesticum fruit peel had cytotoxicity against T-47D cells. However, the study on how these terpenoids induce cell death is still unknown. Flow cytometry analysis was carried out to evaluate the effect of the compounds in cell cycle modulation and apoptotic induction. The terpenoid compounds induced apoptosis and cell cycle arrest in S phase in a dose dependent manner. Compound 1 synergized the effect of doxorubicin in inducing cell death through mechanism involving the cell cycle. Compound 1 revealed better activity in killing T-47D cells rather than compound 2. Further studies are needed to explore the potential of these compounds in promoting cell death of breast cancer. © 2022, Society for Indonesian Biodiversity. All rights reserved. |
| first_indexed | 2024-03-14T00:08:03Z |
| format | Article |
| id | oai:generic.eprints.org:283617 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:08:03Z |
| publishDate | 2022 |
| publisher | Society for Indonesian Biodiversity |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2836172023-11-21T08:18:54Z https://repository.ugm.ac.id/283617/ Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines Fadhilah, Khusnul Wahyuono, Subagus Astuti, Puji Pharmaceutical Sciences One of the characteristics of cancer cells is uncontrolled proliferation. This can be caused by aberrant in the proteins that play a role in the process of apoptosis and cell cycle. Lamesticumin A and 2-ethyl,3-(1’-hydroxy-2’-menthene) propenal have been isolated from ethyl acetate extract of L. domesticum fruit peel had cytotoxicity against T-47D cells. However, the study on how these terpenoids induce cell death is still unknown. Flow cytometry analysis was carried out to evaluate the effect of the compounds in cell cycle modulation and apoptotic induction. The terpenoid compounds induced apoptosis and cell cycle arrest in S phase in a dose dependent manner. Compound 1 synergized the effect of doxorubicin in inducing cell death through mechanism involving the cell cycle. Compound 1 revealed better activity in killing T-47D cells rather than compound 2. Further studies are needed to explore the potential of these compounds in promoting cell death of breast cancer. © 2022, Society for Indonesian Biodiversity. All rights reserved. Society for Indonesian Biodiversity 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283617/1/45_Short%20Communication%20Terpenoids%20isolated%20from%20Lansium%20domesticum%20fruit%20peel%20induce%20apoptosis%20and%20cell%20cycle%20arrest%20in%20T-47D%20cell%20lines.pdf Fadhilah, Khusnul and Wahyuono, Subagus and Astuti, Puji (2022) Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines. Biodiversitas, 23 (2). pp. 1167-1171. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124993597&doi=10.13057%2fbiodiv%2fd230262&partnerID=40&md5=55eedf83239c83db7e2362f87e6b5fd2 |
| spellingShingle | Pharmaceutical Sciences Fadhilah, Khusnul Wahyuono, Subagus Astuti, Puji Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines |
| title | Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines |
| title_full | Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines |
| title_fullStr | Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines |
| title_full_unstemmed | Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines |
| title_short | Short Communication: Terpenoids isolated from Lansium domesticum fruit peel induce apoptosis and cell cycle arrest in T-47D cell lines |
| title_sort | short communication terpenoids isolated from lansium domesticum fruit peel induce apoptosis and cell cycle arrest in t 47d cell lines |
| topic | Pharmaceutical Sciences |
| url | https://repository.ugm.ac.id/283617/1/45_Short%20Communication%20Terpenoids%20isolated%20from%20Lansium%20domesticum%20fruit%20peel%20induce%20apoptosis%20and%20cell%20cycle%20arrest%20in%20T-47D%20cell%20lines.pdf |
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