Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia
Transient pancytopenia due to reactive bone marrow suppression often occurs in hemophagocytic lymphohistiocytosis (HLH), a syndrome resulting from excessive immune activation following a severe infection. We reported two cases with pancytopenia and disseminated histoplasmosis accompanied by HLH, ini...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2022
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| Online Access: | https://repository.ugm.ac.id/283661/1/Add_Novi%20Apriany.pdf |
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| author | Apriany, Novi Sukorini, Usi Ratnaningsih, Tri Asdie, Rizka Humardewayanti Subronto, Yanri Wijayanti Hutajulu, Susanna Hilda Purwanto, Ibnu Hardianti, Mardiah Suci |
| author_facet | Apriany, Novi Sukorini, Usi Ratnaningsih, Tri Asdie, Rizka Humardewayanti Subronto, Yanri Wijayanti Hutajulu, Susanna Hilda Purwanto, Ibnu Hardianti, Mardiah Suci |
| author_sort | Apriany, Novi |
| collection | UGM |
| description | Transient pancytopenia due to reactive bone marrow suppression often occurs in hemophagocytic lymphohistiocytosis (HLH), a syndrome resulting from excessive immune activation following a severe infection. We reported two cases with pancytopenia and disseminated histoplasmosis accompanied by HLH, initially suspected to be blood malignancies. Our first case documented the relevance between the improvement of pancytopenia and the clearance of Histoplasma capsulatum in serial bone marrow aspirations. The second case showed immense Histoplasma engulfment by the macrophage in relation to a severe clinical condition, followed by improvement of clinical symptoms in accordance with the recovery of pancytopenia. These two cases highlighted the importance of comprehensive and critical analysis for cases with concurrent pancytopenia and severe infection, since it may be that the pancytopenia underlies the severe infection or vice versa. |
| first_indexed | 2024-03-14T00:08:11Z |
| format | Article |
| id | oai:generic.eprints.org:283661 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:08:11Z |
| publishDate | 2022 |
| publisher | Hindawi Limited |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2836612023-11-22T00:41:49Z https://repository.ugm.ac.id/283661/ Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia Apriany, Novi Sukorini, Usi Ratnaningsih, Tri Asdie, Rizka Humardewayanti Subronto, Yanri Wijayanti Hutajulu, Susanna Hilda Purwanto, Ibnu Hardianti, Mardiah Suci Clinical Sciences Pathology Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Transient pancytopenia due to reactive bone marrow suppression often occurs in hemophagocytic lymphohistiocytosis (HLH), a syndrome resulting from excessive immune activation following a severe infection. We reported two cases with pancytopenia and disseminated histoplasmosis accompanied by HLH, initially suspected to be blood malignancies. Our first case documented the relevance between the improvement of pancytopenia and the clearance of Histoplasma capsulatum in serial bone marrow aspirations. The second case showed immense Histoplasma engulfment by the macrophage in relation to a severe clinical condition, followed by improvement of clinical symptoms in accordance with the recovery of pancytopenia. These two cases highlighted the importance of comprehensive and critical analysis for cases with concurrent pancytopenia and severe infection, since it may be that the pancytopenia underlies the severe infection or vice versa. Hindawi Limited 2022-12 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283661/1/Add_Novi%20Apriany.pdf Apriany, Novi and Sukorini, Usi and Ratnaningsih, Tri and Asdie, Rizka Humardewayanti and Subronto, Yanri Wijayanti and Hutajulu, Susanna Hilda and Purwanto, Ibnu and Hardianti, Mardiah Suci (2022) Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia. Genetics Research, 2022 (95211). ISSN 14695073 https://www.hindawi.com/journals/crim/2022/9521128/ 10.1155/2022/9521128 |
| spellingShingle | Clinical Sciences Pathology Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Apriany, Novi Sukorini, Usi Ratnaningsih, Tri Asdie, Rizka Humardewayanti Subronto, Yanri Wijayanti Hutajulu, Susanna Hilda Purwanto, Ibnu Hardianti, Mardiah Suci Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia |
| title | Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia |
| title_full | Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia |
| title_fullStr | Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia |
| title_full_unstemmed | Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia |
| title_short | Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia |
| title_sort | two cases of hemophagocytic lymphohistiocytosis associated with disseminated histoplasmosis presented with transient pancytopenia |
| topic | Clinical Sciences Pathology Cancer Therapy (excl. Chemotherapy and Radiation Therapy) |
| url | https://repository.ugm.ac.id/283661/1/Add_Novi%20Apriany.pdf |
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