Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis
Background Neonatal sepsis is a global health problem contribut-ing significantly to neonatal morbidity and mortality. It is difficult to clinically distinguish neonates with and without sepsis. Inter-leukin-6 (IL-6) concentration in neonates has high sensitivity and specificity to predict neonatal...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2022
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| Online Access: | https://repository.ugm.ac.id/283768/1/2702-Article%20Text-11921-1-10-20221102.pdf |
| _version_ | 1826050685779574784 |
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| author | Fadilah, Arya Adnan Haksari, Ekawaty Lutfia Wandita, Setya |
| author_facet | Fadilah, Arya Adnan Haksari, Ekawaty Lutfia Wandita, Setya |
| author_sort | Fadilah, Arya Adnan |
| collection | UGM |
| description | Background Neonatal sepsis is a global health problem contribut-ing significantly to neonatal morbidity and mortality. It is difficult to clinically distinguish neonates with and without sepsis. Inter-leukin-6 (IL-6) concentration in neonates has high sensitivity and specificity to predict neonatal sepsis in infants at risk. Objective To determine the utility of umbilical cord blood IL-6 as a predictor of early-onset neonatal sepsis. Methods This prospective cohort study was conducted in neonates born to mothers with sepsis risk factors from December 2020 to January 2021. We measured IL-6 from umbilical cord blood taken after placental expulsion. IL-6≥16.4 pg/mL was considered to be elevated. Subjects were monitored for signs of clinical sepsis until 72 hours after birth. We also recorded the presence of other maternal and infant risk factors of sepsis and assessed association between IL-6 and other risk factors with the occurrence of sepsis, expressed as relative risk (RR) with 95 confidence interval (95CI). Results During the study period, 40 neonates were born to mothers with sepsis risk factors; 13 (32.5) developed clinical sepsis. Significantly more infants with elevated IL-6 developed neonatal sepsis (55.5) than those with normal IL-6 (13.6). After multi-variate analysis incorporating other significant variables, the risk factors predictive of clinical early-onset neonatal sepsis were IL-6 RR 5.54 (95%CI 1.68-18.25); P=0.016, prematurity RR 4.92 (95%CI 1.66-14.59); P=0.014, and initial Apgar score RR 3.38 (95%CI 1.34-3.38); P=0.046. Conclusion In neonates with maternal risk factors, an IL-6 level of ≥16.4 pg/ml is associated with an increased risk of early-onset neonatal sepsis. © 2022, Indonesian Pediatric Society Publishing House. All rights reserved. |
| first_indexed | 2024-03-14T00:08:30Z |
| format | Article |
| id | oai:generic.eprints.org:283768 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:08:30Z |
| publishDate | 2022 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2837682023-11-22T06:45:46Z https://repository.ugm.ac.id/283768/ Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis Fadilah, Arya Adnan Haksari, Ekawaty Lutfia Wandita, Setya Haematology Paediatrics Background Neonatal sepsis is a global health problem contribut-ing significantly to neonatal morbidity and mortality. It is difficult to clinically distinguish neonates with and without sepsis. Inter-leukin-6 (IL-6) concentration in neonates has high sensitivity and specificity to predict neonatal sepsis in infants at risk. Objective To determine the utility of umbilical cord blood IL-6 as a predictor of early-onset neonatal sepsis. Methods This prospective cohort study was conducted in neonates born to mothers with sepsis risk factors from December 2020 to January 2021. We measured IL-6 from umbilical cord blood taken after placental expulsion. IL-6≥16.4 pg/mL was considered to be elevated. Subjects were monitored for signs of clinical sepsis until 72 hours after birth. We also recorded the presence of other maternal and infant risk factors of sepsis and assessed association between IL-6 and other risk factors with the occurrence of sepsis, expressed as relative risk (RR) with 95 confidence interval (95CI). Results During the study period, 40 neonates were born to mothers with sepsis risk factors; 13 (32.5) developed clinical sepsis. Significantly more infants with elevated IL-6 developed neonatal sepsis (55.5) than those with normal IL-6 (13.6). After multi-variate analysis incorporating other significant variables, the risk factors predictive of clinical early-onset neonatal sepsis were IL-6 RR 5.54 (95%CI 1.68-18.25); P=0.016, prematurity RR 4.92 (95%CI 1.66-14.59); P=0.014, and initial Apgar score RR 3.38 (95%CI 1.34-3.38); P=0.046. Conclusion In neonates with maternal risk factors, an IL-6 level of ≥16.4 pg/ml is associated with an increased risk of early-onset neonatal sepsis. © 2022, Indonesian Pediatric Society Publishing House. All rights reserved. Indonesian Pediatric Society Publishing House 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283768/1/2702-Article%20Text-11921-1-10-20221102.pdf Fadilah, Arya Adnan and Haksari, Ekawaty Lutfia and Wandita, Setya (2022) Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis. Paediatrica Indonesiana(Paediatrica Indonesiana), 62 (5). 304 -310. https://www.scopus.com/ 10.14238/pi62.5.2022.304-10 |
| spellingShingle | Haematology Paediatrics Fadilah, Arya Adnan Haksari, Ekawaty Lutfia Wandita, Setya Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis |
| title | Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis |
| title_full | Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis |
| title_fullStr | Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis |
| title_full_unstemmed | Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis |
| title_short | Umbilical cord blood interleukin-6 level as a predictor of early-onset neonatal sepsis |
| title_sort | umbilical cord blood interleukin 6 level as a predictor of early onset neonatal sepsis |
| topic | Haematology Paediatrics |
| url | https://repository.ugm.ac.id/283768/1/2702-Article%20Text-11921-1-10-20221102.pdf |
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