In-situ synthesis of reduced graphene oxide/silver nanoparticles (rGO/AgNPs) nanocomposites for high loading capacity of acetylsalicylic acid

Graphene has excellent properties which can be a promising material as nanocomposites for application in a drug delivery system (DDS). In this study, reduced graphene oxide/silver nanoparticles (rGO/AgNPs) nanocomposites was synthesized using a facile in-situ method for drug loading application of a...

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Bibliographic Details
Main Authors: Handayani, Murni, Suwaji, Bagus Indra, Asih, Geolita Ihsantia Ning, Kusumaningsih, Triana, Kusumastuti, Yuni, Rochmadi, Rochmadi, Anshori, Isa
Format: Article
Language:English
Published: Taylor & Francis 2022
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Online Access:https://repository.ugm.ac.id/283972/1/Rochmadi_TK.pdf
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Summary:Graphene has excellent properties which can be a promising material as nanocomposites for application in a drug delivery system (DDS). In this study, reduced graphene oxide/silver nanoparticles (rGO/AgNPs) nanocomposites was synthesized using a facile in-situ method for drug loading application of acetylsalicylic acid (ASA). The synthesis results were characterized by FESEM, EDX, UV-Vis, XRD, and Raman spectrophotometers analyses. The results showed that rGO/AgNPs nanocomposites was synthesized successfully. Drug loading application was performed using UV-Vis measurements. The loading results depicted that rGO/AgNPs is successfully created in high-capacity loading for ASA. Drug loading performances enhanced with the increasing loading time of ASA on rGO/AgNPs. The optimum percentage of drug loading capacity for ASA by rGO/AgNPs was ∼83% in a contact time of 30 hrs.