The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia
Blood culturing remains the "gold standard"for bloodstream infection (BSI) diagnosis, but the method is inaccessible to many developing countries due to high costs and insufficient resources. To better understand the utility of blood cultures among patients in Indonesia, a country where bl...
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| Format: | Article |
| Language: | English |
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Public Library of Science
2022
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| Online Access: | https://repository.ugm.ac.id/283993/1/195.pdf |
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| author | Soedarmono, Pratiwi Diana, Aly Tauran, Patricia Lokida, Dewi Aman, Abu Tholib Alisjahbana, Bachti Arlinda, Dona Tjitra, Emiliana Kosasih, Herman Merati, Ketut Tuti Parwati Arif, Mansyur Gasem, Muhammad Hussein Susanto, Nugroho Harry Lukman, Nurhayati Sugiyono, Retna Indah Hadi, Usman Lisdawati, Vivi Tchos, Karine G. Fouth Neal, Aaron Karyana, Muhammad |
| author_facet | Soedarmono, Pratiwi Diana, Aly Tauran, Patricia Lokida, Dewi Aman, Abu Tholib Alisjahbana, Bachti Arlinda, Dona Tjitra, Emiliana Kosasih, Herman Merati, Ketut Tuti Parwati Arif, Mansyur Gasem, Muhammad Hussein Susanto, Nugroho Harry Lukman, Nurhayati Sugiyono, Retna Indah Hadi, Usman Lisdawati, Vivi Tchos, Karine G. Fouth Neal, Aaron Karyana, Muhammad |
| author_sort | Soedarmono, Pratiwi |
| collection | UGM |
| description | Blood culturing remains the "gold standard"for bloodstream infection (BSI) diagnosis, but the method is inaccessible to many developing countries due to high costs and insufficient resources. To better understand the utility of blood cultures among patients in Indonesia, a country where blood cultures are not routinely performed, we evaluated data from a previous cohort study that included blood cultures for all participants. An acute febrile illness study was conducted from July 2013 to June 2016 at eight major hospitals in seven provincial capitals in Indonesia. All participants presented with a fever, and two-sided aerobic blood cultures were performed within 48 hours of hospital admission. Positive cultures were further assessed for antimicrobial resistance (AMR) patterns. Specimens from participants with negative culture results were screened by advanced molecular and serological methods for evidence of causal pathogens. Blood cultures were performed for 1,459 of 1,464 participants, and the 70.6 (1,030) participants that were negative by dengue NS1 antigen test were included in further analysis. Bacteremia was observed in 8.9 (92) participants, with the most frequent pathogens being Salmonella enterica serovar Typhi (41) and Paratyphi A (10), Escherichia coli (14), and Staphylococcus aureus (10). Two S. Paratyphi A cases had evidence of AMR, and several E. coli cases were multidrug resistant (42.9, 6/14) or monoresistant (14.3, 2/14). Culture contamination was observed in 3.6 (37) cases. Molecular and serological assays identified etiological agents in participants having negative cultures, with 23.1 to 90 of cases being missed by blood cultures. Blood cultures are a valuable diagnostic tool for hospitalized patients presenting with fever. In Indonesia, pre-screening patients for the most common viral infections, such as dengue, influenza, and chikungunya viruses, would maximize the benefit to the patient while also conserving resources. Blood cultures should also be supplemented with advanced laboratory tests when available. © 2022 This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
| first_indexed | 2024-03-14T00:09:08Z |
| format | Article |
| id | oai:generic.eprints.org:283993 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:09:08Z |
| publishDate | 2022 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2839932023-11-27T07:39:34Z https://repository.ugm.ac.id/283993/ The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia Soedarmono, Pratiwi Diana, Aly Tauran, Patricia Lokida, Dewi Aman, Abu Tholib Alisjahbana, Bachti Arlinda, Dona Tjitra, Emiliana Kosasih, Herman Merati, Ketut Tuti Parwati Arif, Mansyur Gasem, Muhammad Hussein Susanto, Nugroho Harry Lukman, Nurhayati Sugiyono, Retna Indah Hadi, Usman Lisdawati, Vivi Tchos, Karine G. Fouth Neal, Aaron Karyana, Muhammad Medical Bacteriology Blood culturing remains the "gold standard"for bloodstream infection (BSI) diagnosis, but the method is inaccessible to many developing countries due to high costs and insufficient resources. To better understand the utility of blood cultures among patients in Indonesia, a country where blood cultures are not routinely performed, we evaluated data from a previous cohort study that included blood cultures for all participants. An acute febrile illness study was conducted from July 2013 to June 2016 at eight major hospitals in seven provincial capitals in Indonesia. All participants presented with a fever, and two-sided aerobic blood cultures were performed within 48 hours of hospital admission. Positive cultures were further assessed for antimicrobial resistance (AMR) patterns. Specimens from participants with negative culture results were screened by advanced molecular and serological methods for evidence of causal pathogens. Blood cultures were performed for 1,459 of 1,464 participants, and the 70.6 (1,030) participants that were negative by dengue NS1 antigen test were included in further analysis. Bacteremia was observed in 8.9 (92) participants, with the most frequent pathogens being Salmonella enterica serovar Typhi (41) and Paratyphi A (10), Escherichia coli (14), and Staphylococcus aureus (10). Two S. Paratyphi A cases had evidence of AMR, and several E. coli cases were multidrug resistant (42.9, 6/14) or monoresistant (14.3, 2/14). Culture contamination was observed in 3.6 (37) cases. Molecular and serological assays identified etiological agents in participants having negative cultures, with 23.1 to 90 of cases being missed by blood cultures. Blood cultures are a valuable diagnostic tool for hospitalized patients presenting with fever. In Indonesia, pre-screening patients for the most common viral infections, such as dengue, influenza, and chikungunya viruses, would maximize the benefit to the patient while also conserving resources. Blood cultures should also be supplemented with advanced laboratory tests when available. © 2022 This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Public Library of Science 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283993/1/195.pdf Soedarmono, Pratiwi and Diana, Aly and Tauran, Patricia and Lokida, Dewi and Aman, Abu Tholib and Alisjahbana, Bachti and Arlinda, Dona and Tjitra, Emiliana and Kosasih, Herman and Merati, Ketut Tuti Parwati and Arif, Mansyur and Gasem, Muhammad Hussein and Susanto, Nugroho Harry and Lukman, Nurhayati and Sugiyono, Retna Indah and Hadi, Usman and Lisdawati, Vivi and Tchos, Karine G. Fouth and Neal, Aaron and Karyana, Muhammad (2022) The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia. PLoS ONE, 17 (9 Sept). ISSN 19326203 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0273414 10.1371/journal.pone.0273414 |
| spellingShingle | Medical Bacteriology Soedarmono, Pratiwi Diana, Aly Tauran, Patricia Lokida, Dewi Aman, Abu Tholib Alisjahbana, Bachti Arlinda, Dona Tjitra, Emiliana Kosasih, Herman Merati, Ketut Tuti Parwati Arif, Mansyur Gasem, Muhammad Hussein Susanto, Nugroho Harry Lukman, Nurhayati Sugiyono, Retna Indah Hadi, Usman Lisdawati, Vivi Tchos, Karine G. Fouth Neal, Aaron Karyana, Muhammad The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia |
| title | The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia |
| title_full | The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia |
| title_fullStr | The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia |
| title_full_unstemmed | The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia |
| title_short | The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia |
| title_sort | characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in indonesia |
| topic | Medical Bacteriology |
| url | https://repository.ugm.ac.id/283993/1/195.pdf |
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