Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population
Introduction: Androgen deprivation therapy (ADT) has been the pivotal strategy for treating advanced prostate cancers. Despite the high efficacy of ADT in prohibiting tumor growth, >50% cases of prostate cancer will develop into an aggressive variant known as castration resistant prostate cancer...
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| Format: | Article |
| Language: | English |
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Malaysian Medical Association
2022
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| Online Access: | https://repository.ugm.ac.id/284019/1/v77-Supp-1-2022.pdf |
| _version_ | 1826050732158091264 |
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| author | Soerohardjo, Indrawarman Widodo, Irianiwati Zulfiqqar, Andy Heriyanto, Didik Setyo Anwar, Sumadi Lukman |
| author_facet | Soerohardjo, Indrawarman Widodo, Irianiwati Zulfiqqar, Andy Heriyanto, Didik Setyo Anwar, Sumadi Lukman |
| author_sort | Soerohardjo, Indrawarman |
| collection | UGM |
| description | Introduction: Androgen deprivation therapy (ADT) has been the pivotal strategy for treating advanced prostate cancers. Despite the high efficacy of ADT in prohibiting tumor growth, >50% cases of prostate cancer will develop into an aggressive variant known as castration resistant prostate cancer (CRPC). This study aimed to evaluate the potential role SSRT5-AS1 expression as a biomarker for response to ADT in prostate cancer. Materials and Methods: In total, 36 patients diagnosed with prostate cancer at Dr. Sardjito General Hospital, Yogyakarta, Indonesia were enrolled from 2015 and 2019. The expression of SSRT5-AS1 in primary tumors was quantified using quantitative real-time polymerase chain reaction. Results: The mean age of patients enrolled in this study was 69.07 ± 8.7 years, and the mean of prostate-specific antigen in patients was 141.22 ±112.28 ng/ml. Compared with the median, a higher expression of SSTR5-AS1 had more significant prognostic value than the variable shorter time to CRPC p= 0.043). Conclusion: This study demonstrated that high expression of SSRT5-AS1 is a promising biomarker to predict response to ADT in patients with prostate cancer. |
| first_indexed | 2024-03-14T00:09:13Z |
| format | Article |
| id | oai:generic.eprints.org:284019 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:09:13Z |
| publishDate | 2022 |
| publisher | Malaysian Medical Association |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2840192023-11-28T06:28:38Z https://repository.ugm.ac.id/284019/ Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population Soerohardjo, Indrawarman Widodo, Irianiwati Zulfiqqar, Andy Heriyanto, Didik Setyo Anwar, Sumadi Lukman Oncology and Carcinogenesis Cancer Diagnosis Introduction: Androgen deprivation therapy (ADT) has been the pivotal strategy for treating advanced prostate cancers. Despite the high efficacy of ADT in prohibiting tumor growth, >50% cases of prostate cancer will develop into an aggressive variant known as castration resistant prostate cancer (CRPC). This study aimed to evaluate the potential role SSRT5-AS1 expression as a biomarker for response to ADT in prostate cancer. Materials and Methods: In total, 36 patients diagnosed with prostate cancer at Dr. Sardjito General Hospital, Yogyakarta, Indonesia were enrolled from 2015 and 2019. The expression of SSRT5-AS1 in primary tumors was quantified using quantitative real-time polymerase chain reaction. Results: The mean age of patients enrolled in this study was 69.07 ± 8.7 years, and the mean of prostate-specific antigen in patients was 141.22 ±112.28 ng/ml. Compared with the median, a higher expression of SSTR5-AS1 had more significant prognostic value than the variable shorter time to CRPC p= 0.043). Conclusion: This study demonstrated that high expression of SSRT5-AS1 is a promising biomarker to predict response to ADT in patients with prostate cancer. Malaysian Medical Association 2022-07 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/284019/1/v77-Supp-1-2022.pdf Soerohardjo, Indrawarman and Widodo, Irianiwati and Zulfiqqar, Andy and Heriyanto, Didik Setyo and Anwar, Sumadi Lukman (2022) Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population. Medical Journal of Malaysia, 77 (Supp 1). pp. 1-4. ISSN 0300-5283 https://www.e-mjm.org/2022/v77s1/v77-Supp-1-2022.pdf 35899879 |
| spellingShingle | Oncology and Carcinogenesis Cancer Diagnosis Soerohardjo, Indrawarman Widodo, Irianiwati Zulfiqqar, Andy Heriyanto, Didik Setyo Anwar, Sumadi Lukman Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population |
| title | Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population |
| title_full | Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population |
| title_fullStr | Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population |
| title_full_unstemmed | Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population |
| title_short | Role of somatostatin receptor SSRT5-AS1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in Indonesian population |
| title_sort | role of somatostatin receptor ssrt5 as1 in predicting biomarkers of primary androgen deprivation therapy on prostate cancer in indonesian population |
| topic | Oncology and Carcinogenesis Cancer Diagnosis |
| url | https://repository.ugm.ac.id/284019/1/v77-Supp-1-2022.pdf |
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