The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study
Background: Sepsis is one of the main causes in burn victim's mortality. The use of negative pressure wound therapy (NPWT) provides an ideal environment to accelerate wound healing. We compare the use of normal saline (NS), intermittent NPWT, continuous NPWT and silver sulfadiazine in wound hea...
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| Format: | Article |
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Elsevier Ltd
2022
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| author | Resadita, Reagan Seswandhana, M. Rosadi Purnomo, Eko Anzhari, Sharfan Gabriela, Gita Christy Dachlan, Ishandono Aryandono, Teguh Wirohadidjojo, Yohanes Widodo |
| author_facet | Resadita, Reagan Seswandhana, M. Rosadi Purnomo, Eko Anzhari, Sharfan Gabriela, Gita Christy Dachlan, Ishandono Aryandono, Teguh Wirohadidjojo, Yohanes Widodo |
| author_sort | Resadita, Reagan |
| collection | UGM |
| description | Background: Sepsis is one of the main causes in burn victim's mortality. The use of negative pressure wound therapy (NPWT) provides an ideal environment to accelerate wound healing. We compare the use of normal saline (NS), intermittent NPWT, continuous NPWT and silver sulfadiazine in wound healing process. Method: This study involved 6 Yorkshire pigs; each pig was induced with 20 burns on the flank area. Burns were divided into 4 treatment groups: NS gauze, intermittent NPWT, continuous NPWT, and silver sulfadiazine dressing. Burns were evaluated on day 1,3,7,14, and 21 for its morphology and bacterial colonization and on day 14 and 21 for the remaining burn surface area. Result: Wound that received NPWT therapy appeared better in both granulation and crust formation. Remaining burn surface area (mm2) on day 14 in NS group, intermittent NPWT, continuous NPWT, and silver sulfadiazine were 107.43 ± 83.43, 178.07 ± 74.83, 146.10 ± 69.1, 126.03 ± 83.22, respectively(p = 0.457); on day 21 in NS group, intermittent NPWT, continuous NPWT, and silver sulfadiazine were 13.16 ± 16.86, 59.49 ± 20.72, 54.79 ± 46.59, 48.95 ± 39.84, respectively(p=0.169). There were no significant differences in each treatment group bacterial colonization(p>0.05). There were no significant correlation between bacterial colonization and remaining burn surface area (p>0.05). Conclusion: While morphologically, the wound in NPWT treatment groups appeared better in granulation and crust formation, the remaining wound surface area and the number of bacterial colonization were not significantly difference compared to standard therapy (silver sulfadiazine and NS gauze). There were no significant correlation between the amount of bacterial colonization and remaining wound surface area on every treatment group. © 2022 |
| first_indexed | 2024-03-14T00:09:14Z |
| format | Article |
| id | oai:generic.eprints.org:284025 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-14T00:09:14Z |
| publishDate | 2022 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2840252023-11-27T08:53:11Z https://repository.ugm.ac.id/284025/ The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study Resadita, Reagan Seswandhana, M. Rosadi Purnomo, Eko Anzhari, Sharfan Gabriela, Gita Christy Dachlan, Ishandono Aryandono, Teguh Wirohadidjojo, Yohanes Widodo Surgery Background: Sepsis is one of the main causes in burn victim's mortality. The use of negative pressure wound therapy (NPWT) provides an ideal environment to accelerate wound healing. We compare the use of normal saline (NS), intermittent NPWT, continuous NPWT and silver sulfadiazine in wound healing process. Method: This study involved 6 Yorkshire pigs; each pig was induced with 20 burns on the flank area. Burns were divided into 4 treatment groups: NS gauze, intermittent NPWT, continuous NPWT, and silver sulfadiazine dressing. Burns were evaluated on day 1,3,7,14, and 21 for its morphology and bacterial colonization and on day 14 and 21 for the remaining burn surface area. Result: Wound that received NPWT therapy appeared better in both granulation and crust formation. Remaining burn surface area (mm2) on day 14 in NS group, intermittent NPWT, continuous NPWT, and silver sulfadiazine were 107.43 ± 83.43, 178.07 ± 74.83, 146.10 ± 69.1, 126.03 ± 83.22, respectively(p = 0.457); on day 21 in NS group, intermittent NPWT, continuous NPWT, and silver sulfadiazine were 13.16 ± 16.86, 59.49 ± 20.72, 54.79 ± 46.59, 48.95 ± 39.84, respectively(p=0.169). There were no significant differences in each treatment group bacterial colonization(p>0.05). There were no significant correlation between bacterial colonization and remaining burn surface area (p>0.05). Conclusion: While morphologically, the wound in NPWT treatment groups appeared better in granulation and crust formation, the remaining wound surface area and the number of bacterial colonization were not significantly difference compared to standard therapy (silver sulfadiazine and NS gauze). There were no significant correlation between the amount of bacterial colonization and remaining wound surface area on every treatment group. © 2022 Elsevier Ltd 2022 Article PeerReviewed Resadita, Reagan and Seswandhana, M. Rosadi and Purnomo, Eko and Anzhari, Sharfan and Gabriela, Gita Christy and Dachlan, Ishandono and Aryandono, Teguh and Wirohadidjojo, Yohanes Widodo (2022) The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study. Annals of Medicine and Surgery, 75. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125674386&doi=10.1016%2fj.amsu.2022.103367&partnerID=40&md5=a1ba29394a3079da4fd59823fd1ce5d6 10.1016/j.amsu.2022.103367 |
| spellingShingle | Surgery Resadita, Reagan Seswandhana, M. Rosadi Purnomo, Eko Anzhari, Sharfan Gabriela, Gita Christy Dachlan, Ishandono Aryandono, Teguh Wirohadidjojo, Yohanes Widodo The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study |
| title | The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study |
| title_full | The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study |
| title_fullStr | The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study |
| title_full_unstemmed | The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study |
| title_short | The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study |
| title_sort | effect of npwt in wound healing and bacterial count on deep dermal burn injury model an experimental study |
| topic | Surgery |
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