The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement
Objectives: To analyze the effect of risedronate hydrogel on enzyme alkaline phosphatase (ALP) and osteoclast/osteoblast ratio during tooth relapse movement Materials and methods: The research design is experimental with time series. The lower incisors of 75 guinea pigs are distally moved using open...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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2022
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| Online Access: | https://repository.ugm.ac.id/284071/1/10.7126-cumudj.932462-1750007.pdf |
| _version_ | 1797037791601754112 |
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| author | Utari, Tita Ratya Pudyani, Pinandi Sri Ana, Ika Dewi Asmara, Widya |
| author_facet | Utari, Tita Ratya Pudyani, Pinandi Sri Ana, Ika Dewi Asmara, Widya |
| author_sort | Utari, Tita Ratya |
| collection | UGM |
| description | Objectives: To analyze the effect of risedronate hydrogel on enzyme alkaline phosphatase (ALP) and osteoclast/osteoblast ratio during tooth relapse movement Materials and methods: The research design is experimental with time series. The lower incisors of 75 guinea pigs are distally moved using open coil spring. The guinea pigs were divided into three groups: without risedronate (group A; n = 25); given 250 μmol/L of risedronate hydrogel (group B; n = 25), and given 500 μmol/L of risedronate hydrogel (group C; n = 25). Risedronate were applied intrasulcularly in the mesial part of the gingival sulcus every 3 days. After 14 days of stabilization, the open coil spring was removed (bisphosphonate administration was continued). The relapsed teeth and ALP levels on days 0, 3, 7, 14, and 21 were measured. The osteoclast/osteoblast ratio was measured by hematoxylin and eosin staining. ANOVA test was used to determine the difference in the three groups and their interactions with concentration and time. Results: There was a significant difference in osteoclast/osteoblast ratio on day 3 and 14 the ratio was higher in group A than in groups B and C on day 3, and the ratio was higher in group C than in groups A and B on day 14. ALP levels were significantly different on day 14 and 21. Conclusions: The intrasulcular application of bisphosphonate risedronate affected the osteoclast/osteoblast ratio and increased ALP levels. |
| first_indexed | 2024-03-14T00:09:22Z |
| format | Article |
| id | oai:generic.eprints.org:284071 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:09:22Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2840712023-11-27T08:18:15Z https://repository.ugm.ac.id/284071/ The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement Utari, Tita Ratya Pudyani, Pinandi Sri Ana, Ika Dewi Asmara, Widya Dentistry not elsewhere classified Objectives: To analyze the effect of risedronate hydrogel on enzyme alkaline phosphatase (ALP) and osteoclast/osteoblast ratio during tooth relapse movement Materials and methods: The research design is experimental with time series. The lower incisors of 75 guinea pigs are distally moved using open coil spring. The guinea pigs were divided into three groups: without risedronate (group A; n = 25); given 250 μmol/L of risedronate hydrogel (group B; n = 25), and given 500 μmol/L of risedronate hydrogel (group C; n = 25). Risedronate were applied intrasulcularly in the mesial part of the gingival sulcus every 3 days. After 14 days of stabilization, the open coil spring was removed (bisphosphonate administration was continued). The relapsed teeth and ALP levels on days 0, 3, 7, 14, and 21 were measured. The osteoclast/osteoblast ratio was measured by hematoxylin and eosin staining. ANOVA test was used to determine the difference in the three groups and their interactions with concentration and time. Results: There was a significant difference in osteoclast/osteoblast ratio on day 3 and 14 the ratio was higher in group A than in groups B and C on day 3, and the ratio was higher in group C than in groups A and B on day 14. ALP levels were significantly different on day 14 and 21. Conclusions: The intrasulcular application of bisphosphonate risedronate affected the osteoclast/osteoblast ratio and increased ALP levels. 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/284071/1/10.7126-cumudj.932462-1750007.pdf Utari, Tita Ratya and Pudyani, Pinandi Sri and Ana, Ika Dewi and Asmara, Widya (2022) The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement. Cumhuriyet Dental Journal, 25 (2). pp. 103-110. https://www.scopus.com/record/display.uri?eid=2-s2.0-85133461697&origin=resultslist&sort=plf-f&src=s&sid=8fb50ae0b5611e36b4802bff31e85162&sot=b&sdt=b&s=TITLE-ABS-KEY%28The+Potential+of+Bisphosphonate+Risedronate+Hydrogel+in+Preventing+Relapse+Movement%3B+%5BOrtodontik+N%C3%BCks+Hareketi%29&sl=125&sessionSearchId=8fb50ae0b5611e36b4802bff31e85162 |
| spellingShingle | Dentistry not elsewhere classified Utari, Tita Ratya Pudyani, Pinandi Sri Ana, Ika Dewi Asmara, Widya The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement |
| title | The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement |
| title_full | The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement |
| title_fullStr | The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement |
| title_full_unstemmed | The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement |
| title_short | The Potential of Bisphosphonate Risedronate Hydrogel in Preventing Relapse Movement |
| title_sort | potential of bisphosphonate risedronate hydrogel in preventing relapse movement |
| topic | Dentistry not elsewhere classified |
| url | https://repository.ugm.ac.id/284071/1/10.7126-cumudj.932462-1750007.pdf |
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