Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study
Background: Differentiated thyroid cancer has excellent overall survival. However, around 20% of patients experience recurrent diseases after a certain time of follow-up. Therefore, identification of risk factors for recurrence is necessary to adjust treatment and surveillance planning. Methods: A r...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central Ltd
2022
|
| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/284256/1/Anwar_KKMK.pdf |
| _version_ | 1826050771064455168 |
|---|---|
| author | Anwar, Sumadi Lukman Cahyono, Roby Suwardjo, Suwardjo Hardiyanto, Herjuna |
| author_facet | Anwar, Sumadi Lukman Cahyono, Roby Suwardjo, Suwardjo Hardiyanto, Herjuna |
| author_sort | Anwar, Sumadi Lukman |
| collection | UGM |
| description | Background: Differentiated thyroid cancer has excellent overall survival. However, around 20% of patients experience recurrent diseases after a certain time of follow-up. Therefore, identification of risk factors for recurrence is necessary to adjust treatment and surveillance planning. Methods: A retrospective study was conducted of 312 patients with differentiated thyroid cancer who received surgery with and without adjuvant treatment. Clinical and pathological risk factors were analyzed for recurrences. Results: After median follow-up of 57 months, 109 of 312 patients (34.9%) developed recurrences. Extrathyroidal extension and positive cervical nodes were significantly associated with recurrences (OR = 2.449, 95%CI:1.260–4.760, P = 0.008 and OR = 3.511, 95%CI:1.860–6.626, P < 0.001; respectively). Lympho-vascular invasion (LVI) and tumor multifocality were also associated with increased risk of recurrence (OR = 2.577, 95%CI:1.380–4.812, P = 0.003 and OR = 1.602, 95%CI:1.001–2.495, P = 0.050; respectively). Using multivariable regression, only older age and tumor infiltration to the lymph nodes were significantly associated with recurrences (OR = 2.227, 95%CI:1.037–4.782, P = 0.040 and OR = 2.966, 95%CI:1.470–5.986, P = 0.002; respectively). In addition, T4, cervical lymph node infiltration, older age, and LVI were associated with shorter recurrence-free survival. Conclusion: Recurrence rates in our study population are relatively high. Extrathyroidal extension, positive neck lymph node, and older age were associated with recurrence risks of well differentiated thyroid cancers. |
| first_indexed | 2024-03-14T00:09:49Z |
| format | Article |
| id | oai:generic.eprints.org:284256 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:09:49Z |
| publishDate | 2022 |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2842562023-12-01T03:41:18Z https://repository.ugm.ac.id/284256/ Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study Anwar, Sumadi Lukman Cahyono, Roby Suwardjo, Suwardjo Hardiyanto, Herjuna Clinical Sciences Surgery Background: Differentiated thyroid cancer has excellent overall survival. However, around 20% of patients experience recurrent diseases after a certain time of follow-up. Therefore, identification of risk factors for recurrence is necessary to adjust treatment and surveillance planning. Methods: A retrospective study was conducted of 312 patients with differentiated thyroid cancer who received surgery with and without adjuvant treatment. Clinical and pathological risk factors were analyzed for recurrences. Results: After median follow-up of 57 months, 109 of 312 patients (34.9%) developed recurrences. Extrathyroidal extension and positive cervical nodes were significantly associated with recurrences (OR = 2.449, 95%CI:1.260–4.760, P = 0.008 and OR = 3.511, 95%CI:1.860–6.626, P < 0.001; respectively). Lympho-vascular invasion (LVI) and tumor multifocality were also associated with increased risk of recurrence (OR = 2.577, 95%CI:1.380–4.812, P = 0.003 and OR = 1.602, 95%CI:1.001–2.495, P = 0.050; respectively). Using multivariable regression, only older age and tumor infiltration to the lymph nodes were significantly associated with recurrences (OR = 2.227, 95%CI:1.037–4.782, P = 0.040 and OR = 2.966, 95%CI:1.470–5.986, P = 0.002; respectively). In addition, T4, cervical lymph node infiltration, older age, and LVI were associated with shorter recurrence-free survival. Conclusion: Recurrence rates in our study population are relatively high. Extrathyroidal extension, positive neck lymph node, and older age were associated with recurrence risks of well differentiated thyroid cancers. BioMed Central Ltd 2022-07-26 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/284256/1/Anwar_KKMK.pdf Anwar, Sumadi Lukman and Cahyono, Roby and Suwardjo, Suwardjo and Hardiyanto, Herjuna (2022) Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study. Thyroid Research, 15 (13). pp. 1-8. ISSN 17566614 https://thyroidresearchjournal.biomedcentral.com/articles/10.1186/s13044-022-00131-7 https://doi.org/10.1186/s13044-022-00131-7 |
| spellingShingle | Clinical Sciences Surgery Anwar, Sumadi Lukman Cahyono, Roby Suwardjo, Suwardjo Hardiyanto, Herjuna Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study |
| title | Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study |
| title_full | Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study |
| title_fullStr | Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study |
| title_full_unstemmed | Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study |
| title_short | Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study |
| title_sort | extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence free survival in differentiated thyroid cancer a cohort study |
| topic | Clinical Sciences Surgery |
| url | https://repository.ugm.ac.id/284256/1/Anwar_KKMK.pdf |
| work_keys_str_mv | AT anwarsumadilukman extrathyroidalextensionandcervicalnodeinfiltrationareassociatedwithrecurrencesandshorterrecurrencefreesurvivalindifferentiatedthyroidcanceracohortstudy AT cahyonoroby extrathyroidalextensionandcervicalnodeinfiltrationareassociatedwithrecurrencesandshorterrecurrencefreesurvivalindifferentiatedthyroidcanceracohortstudy AT suwardjosuwardjo extrathyroidalextensionandcervicalnodeinfiltrationareassociatedwithrecurrencesandshorterrecurrencefreesurvivalindifferentiatedthyroidcanceracohortstudy AT hardiyantoherjuna extrathyroidalextensionandcervicalnodeinfiltrationareassociatedwithrecurrencesandshorterrecurrencefreesurvivalindifferentiatedthyroidcanceracohortstudy |