Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based and Its In-vitro Antibacterial Test
. Pyrazoline has been reported with a broad spectrum of biological activity. The presence of the withdrawing group especially the 4-nitrophenyl group in the 3th ring of pyrazoline has never been performed. A new derivative of 2- pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly...
| Main Authors: | , |
|---|---|
| Format: | Other |
| Language: | English |
| Published: |
AIP Conference Proceedings
2022
|
| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/284317/1/Synthesis%20of%203-.pdf |
| Summary: | . Pyrazoline has been reported with a broad spectrum of biological activity. The presence of the withdrawing
group especially the 4-nitrophenyl group in the 3th ring of pyrazoline has never been performed. A new derivative of 2-
pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly, pyrazoline was synthesized by cyclization of
chalcone and hydrazine hydrate without acetate acid as a catalyst. Reactants were refluxed for 30 hours and controlled by
Thin Layer Chromatography (TLC). The result showed that the reaction yielded 45.07% red solid pyrazoline.
Characterization of the structure was confirmed by FTIR and 1H- NMR spectra. However, in vitro antibacterial study
showed that the compound has very low antibacterial activity. |
|---|