Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based and Its In-vitro Antibacterial Test
. Pyrazoline has been reported with a broad spectrum of biological activity. The presence of the withdrawing group especially the 4-nitrophenyl group in the 3th ring of pyrazoline has never been performed. A new derivative of 2- pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly...
| Main Authors: | , |
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| Format: | Other |
| Language: | English |
| Published: |
AIP Conference Proceedings
2022
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/284317/1/Synthesis%20of%203-.pdf |
| _version_ | 1797037833378070528 |
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| author | Fauzi’ah, Lina Wahyuningsih, Tutik Dwi |
| author_facet | Fauzi’ah, Lina Wahyuningsih, Tutik Dwi |
| author_sort | Fauzi’ah, Lina |
| collection | UGM |
| description | . Pyrazoline has been reported with a broad spectrum of biological activity. The presence of the withdrawing
group especially the 4-nitrophenyl group in the 3th ring of pyrazoline has never been performed. A new derivative of 2-
pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly, pyrazoline was synthesized by cyclization of
chalcone and hydrazine hydrate without acetate acid as a catalyst. Reactants were refluxed for 30 hours and controlled by
Thin Layer Chromatography (TLC). The result showed that the reaction yielded 45.07% red solid pyrazoline.
Characterization of the structure was confirmed by FTIR and 1H- NMR spectra. However, in vitro antibacterial study
showed that the compound has very low antibacterial activity. |
| first_indexed | 2024-03-14T00:10:00Z |
| format | Other |
| id | oai:generic.eprints.org:284317 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:10:00Z |
| publishDate | 2022 |
| publisher | AIP Conference Proceedings |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2843172023-12-11T07:53:35Z https://repository.ugm.ac.id/284317/ Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based and Its In-vitro Antibacterial Test Fauzi’ah, Lina Wahyuningsih, Tutik Dwi Organic Chemistry . Pyrazoline has been reported with a broad spectrum of biological activity. The presence of the withdrawing group especially the 4-nitrophenyl group in the 3th ring of pyrazoline has never been performed. A new derivative of 2- pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly, pyrazoline was synthesized by cyclization of chalcone and hydrazine hydrate without acetate acid as a catalyst. Reactants were refluxed for 30 hours and controlled by Thin Layer Chromatography (TLC). The result showed that the reaction yielded 45.07% red solid pyrazoline. Characterization of the structure was confirmed by FTIR and 1H- NMR spectra. However, in vitro antibacterial study showed that the compound has very low antibacterial activity. AIP Conference Proceedings 2022 Other NonPeerReviewed application/pdf en https://repository.ugm.ac.id/284317/1/Synthesis%20of%203-.pdf Fauzi’ah, Lina and Wahyuningsih, Tutik Dwi (2022) Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based and Its In-vitro Antibacterial Test. AIP Conference Proceedings. https://www.researchgate.net/publication/366674704_Synthesis_of_3-4'-nitrophenyl-45-dihydro_pyrazole-based_and_its_in-vitro_antibacterial_test/link/65367b4173a2865c7acbafe7/download?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uIn19 10.1063/5.0103273 |
| spellingShingle | Organic Chemistry Fauzi’ah, Lina Wahyuningsih, Tutik Dwi Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based and Its In-vitro Antibacterial Test |
| title | Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based
and Its In-vitro Antibacterial Test |
| title_full | Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based
and Its In-vitro Antibacterial Test |
| title_fullStr | Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based
and Its In-vitro Antibacterial Test |
| title_full_unstemmed | Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based
and Its In-vitro Antibacterial Test |
| title_short | Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based
and Its In-vitro Antibacterial Test |
| title_sort | synthesis of 3 4 nitrophenyl 4 5 dihydro pyrazole based and its in vitro antibacterial test |
| topic | Organic Chemistry |
| url | https://repository.ugm.ac.id/284317/1/Synthesis%20of%203-.pdf |
| work_keys_str_mv | AT fauziahlina synthesisof34nitrophenyl45dihydropyrazolebasedanditsinvitroantibacterialtest AT wahyuningsihtutikdwi synthesisof34nitrophenyl45dihydropyrazolebasedanditsinvitroantibacterialtest |