Efficacy of C-10 massoialactone against-multispecies microbial biofilm
Biofilm is a community of Microbes found in almost all habitats. They bind to the surface and become incorporated in the biomolecule-rich extracellular matrix. The matrix can fully Microorganisms are covered and rendered more immune to antibacterial agents, becoming a progressive infection source. A...
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| Format: | Article |
| Language: | English |
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AMG Transcend Association
2021
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| Online Access: | https://repository.ugm.ac.id/284352/1/Pratiwi_FA.pdf |
| _version_ | 1797037839712518144 |
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| author | Hamzah, Hasyrul Pratiwi, Sylvia Utami Tunjung Hertiani, Triana |
| author_facet | Hamzah, Hasyrul Pratiwi, Sylvia Utami Tunjung Hertiani, Triana |
| author_sort | Hamzah, Hasyrul |
| collection | UGM |
| description | Biofilm is a community of Microbes found in almost all habitats. They bind to the surface and become incorporated in the biomolecule-rich extracellular matrix. The matrix can fully Microorganisms are covered and rendered more immune to antibacterial agents, becoming a progressive infection source. Anti-biofilm compounds need to be discovered to deal with these biofilm-mediated infections. C-10 Massoialactone(C10H16O2), a significant component of MassoiaaromaticaBecc. The essential oil has demonstrated that antibacterial and anti-fungal properties are possible. This study aims to see how effective C-10 Massoialactone is against multi-species microbial biofilm of Candida albicans, Pseudomonas aeruginosa, and Escherichia coli. Massoia lactone It is derived from the essential oil of Massoiaaromatica bark. To isolate and explain these compounds, researchers used preparative thin layer chromatography (TLC), gas chromatography-mass spectrometry (GC-MS), with 1D-1H nuclear magnetic resonance (NMR) analysis. The impact of horse-tail lactone on several microbial biofilms was investigated. The biofilm structure was analyzed using a transmission electron microscope (TEM) and scanning electron microscope (SEM) the biofilm structure. GCMS and NMR results revealed the presence of C-10 Massoialactone (96.59 %). C-10 Massoialactoneshowed a dosedependent activity in inhibiting biofilm formation as well as in breaking down established biofilms. Higher concentrations of C-10 Massoialactoneare required to inhibit the mature phase of the tested biofilm. TEM and SEM analysis showed apparent cell lysis in the biofilm in the presence of C-10 Massoialactone. C-10 Massoialactone can function because of its rich potential as a new anti-biofilm drug for various microbial biofilms. |
| first_indexed | 2024-03-14T00:10:06Z |
| format | Article |
| id | oai:generic.eprints.org:284352 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:10:06Z |
| publishDate | 2021 |
| publisher | AMG Transcend Association |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2843522023-12-15T06:26:45Z https://repository.ugm.ac.id/284352/ Efficacy of C-10 massoialactone against-multispecies microbial biofilm Hamzah, Hasyrul Pratiwi, Sylvia Utami Tunjung Hertiani, Triana Pharmacology and Pharmaceutical Sciences Biofilm is a community of Microbes found in almost all habitats. They bind to the surface and become incorporated in the biomolecule-rich extracellular matrix. The matrix can fully Microorganisms are covered and rendered more immune to antibacterial agents, becoming a progressive infection source. Anti-biofilm compounds need to be discovered to deal with these biofilm-mediated infections. C-10 Massoialactone(C10H16O2), a significant component of MassoiaaromaticaBecc. The essential oil has demonstrated that antibacterial and anti-fungal properties are possible. This study aims to see how effective C-10 Massoialactone is against multi-species microbial biofilm of Candida albicans, Pseudomonas aeruginosa, and Escherichia coli. Massoia lactone It is derived from the essential oil of Massoiaaromatica bark. To isolate and explain these compounds, researchers used preparative thin layer chromatography (TLC), gas chromatography-mass spectrometry (GC-MS), with 1D-1H nuclear magnetic resonance (NMR) analysis. The impact of horse-tail lactone on several microbial biofilms was investigated. The biofilm structure was analyzed using a transmission electron microscope (TEM) and scanning electron microscope (SEM) the biofilm structure. GCMS and NMR results revealed the presence of C-10 Massoialactone (96.59 %). C-10 Massoialactoneshowed a dosedependent activity in inhibiting biofilm formation as well as in breaking down established biofilms. Higher concentrations of C-10 Massoialactoneare required to inhibit the mature phase of the tested biofilm. TEM and SEM analysis showed apparent cell lysis in the biofilm in the presence of C-10 Massoialactone. C-10 Massoialactone can function because of its rich potential as a new anti-biofilm drug for various microbial biofilms. AMG Transcend Association 2021-08-09 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/284352/1/Pratiwi_FA.pdf Hamzah, Hasyrul and Pratiwi, Sylvia Utami Tunjung and Hertiani, Triana (2021) Efficacy of C-10 massoialactone against-multispecies microbial biofilm. Biointerface Research in Applied Chemistry, 12 (3). pp. 3472-3487. ISSN 20695837 https://www.scopus.com/record/display.uri?eid=2-s2.0-85112371633&doi=10.33263%2fBRIAC123.34723487&origin=inward&txGid=14eff8b4a39f87506d8f90655305a078 https://doi.org/10.33263/BRIAC123.34723487 |
| spellingShingle | Pharmacology and Pharmaceutical Sciences Hamzah, Hasyrul Pratiwi, Sylvia Utami Tunjung Hertiani, Triana Efficacy of C-10 massoialactone against-multispecies microbial biofilm |
| title | Efficacy of C-10 massoialactone against-multispecies microbial biofilm |
| title_full | Efficacy of C-10 massoialactone against-multispecies microbial biofilm |
| title_fullStr | Efficacy of C-10 massoialactone against-multispecies microbial biofilm |
| title_full_unstemmed | Efficacy of C-10 massoialactone against-multispecies microbial biofilm |
| title_short | Efficacy of C-10 massoialactone against-multispecies microbial biofilm |
| title_sort | efficacy of c 10 massoialactone against multispecies microbial biofilm |
| topic | Pharmacology and Pharmaceutical Sciences |
| url | https://repository.ugm.ac.id/284352/1/Pratiwi_FA.pdf |
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