Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
The controlled delivery of antibiotics, anti-inflammatory agents, or chemotherapeutic agents to the periodontal site is a recognized strategy to improve the efficiency of regenerative processes of hard tissues. A novel approach based on the trapping of tetracycline hydrochloride–loaded particles...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE
2013
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| Online Access: | http://irep.iium.edu.my/28713/1/trapping_TCH_nanofibers.pdf |
| _version_ | 1825647125068775424 |
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| author | Wan Abdul Khodir, WK Guarino, V Alvarez Perez, MA Cafiero, C Ambrosio, L |
| author_facet | Wan Abdul Khodir, WK Guarino, V Alvarez Perez, MA Cafiero, C Ambrosio, L |
| author_sort | Wan Abdul Khodir, WK |
| collection | IIUM |
| description | The controlled delivery of antibiotics, anti-inflammatory agents, or chemotherapeutic agents to
the periodontal site is a recognized strategy to improve the efficiency of regenerative processes of
hard tissues. A novel approach based on the trapping of tetracycline hydrochloride–loaded particles
in polycaprolactone nanofibers was used to guide the regeneration processes of periodontal
tissue at the gum interface. Chitosan nanoparticles loaded with different levels of tetracycline
hydrochloride (up to 5% wt) were prepared by solution nebulization induced by electrical forces
(i.e. electrospraying). The fine tuning of process parameters allows to obtain nanoparticles with
tailored sizes ranging from 0.485 ± 0.147 μm to 0.639 ± 0.154 μm. The tetracycline hydrochloride
release profile had a predominant burst effect for the first 70% of release followed by a relatively
slow release over 24 h, which is promising for oral drug delivery. We also demonstrated that
trapping tetracycline hydrochloride–loaded particles with submicrometer diameters into a
polycaprolactone fiber network contributed to slowing the release of tetracycline hydrochloride
from the nanoparticles, thus providing a more prolonged release in the periodontal pocket during
clinical therapy. Preliminary studies on human mesenchymal stem cells confirm the viability of
cells up to 5 days after culture, and thereby, validate the use of nanoparticle-/nanofiber-integrated
systems in periodontal therapies |
| first_indexed | 2024-03-05T23:12:58Z |
| format | Article |
| id | oai:generic.eprints.org:28713 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-13T19:07:58Z |
| publishDate | 2013 |
| publisher | SAGE |
| record_format | dspace |
| spelling | oai:generic.eprints.org:287132014-02-04T06:26:26Z http://irep.iium.edu.my/28713/ Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy. Wan Abdul Khodir, WK Guarino, V Alvarez Perez, MA Cafiero, C Ambrosio, L Q Science (General) The controlled delivery of antibiotics, anti-inflammatory agents, or chemotherapeutic agents to the periodontal site is a recognized strategy to improve the efficiency of regenerative processes of hard tissues. A novel approach based on the trapping of tetracycline hydrochloride–loaded particles in polycaprolactone nanofibers was used to guide the regeneration processes of periodontal tissue at the gum interface. Chitosan nanoparticles loaded with different levels of tetracycline hydrochloride (up to 5% wt) were prepared by solution nebulization induced by electrical forces (i.e. electrospraying). The fine tuning of process parameters allows to obtain nanoparticles with tailored sizes ranging from 0.485 ± 0.147 μm to 0.639 ± 0.154 μm. The tetracycline hydrochloride release profile had a predominant burst effect for the first 70% of release followed by a relatively slow release over 24 h, which is promising for oral drug delivery. We also demonstrated that trapping tetracycline hydrochloride–loaded particles with submicrometer diameters into a polycaprolactone fiber network contributed to slowing the release of tetracycline hydrochloride from the nanoparticles, thus providing a more prolonged release in the periodontal pocket during clinical therapy. Preliminary studies on human mesenchymal stem cells confirm the viability of cells up to 5 days after culture, and thereby, validate the use of nanoparticle-/nanofiber-integrated systems in periodontal therapies SAGE 2013-05-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28713/1/trapping_TCH_nanofibers.pdf Wan Abdul Khodir, WK and Guarino, V and Alvarez Perez, MA and Cafiero, C and Ambrosio, L (2013) Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy. Journal of Bioactive and Compatible Polymer, 28 (3). pp. 258-273. ISSN 0883-9115 http://jbc.sagepub.com/content/28/3/258.full.pdf+html 10.1177/0883911513481133 |
| spellingShingle | Q Science (General) Wan Abdul Khodir, WK Guarino, V Alvarez Perez, MA Cafiero, C Ambrosio, L Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy. |
| title | Trapping tetracycline loaded nanoparticles into
polycaprolactone fiber networks for periodontal
regeneration therapy.
|
| title_full | Trapping tetracycline loaded nanoparticles into
polycaprolactone fiber networks for periodontal
regeneration therapy.
|
| title_fullStr | Trapping tetracycline loaded nanoparticles into
polycaprolactone fiber networks for periodontal
regeneration therapy.
|
| title_full_unstemmed | Trapping tetracycline loaded nanoparticles into
polycaprolactone fiber networks for periodontal
regeneration therapy.
|
| title_short | Trapping tetracycline loaded nanoparticles into
polycaprolactone fiber networks for periodontal
regeneration therapy.
|
| title_sort | trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/28713/1/trapping_TCH_nanofibers.pdf |
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