HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE
The objective of this study is to determine the hepatoprotective effect of GVT-O(one of curcumin analogues) against liver damage in rat-induced D-galactosamine (D-GaIN)/lipopolysaccharide (LPS) as a model of fulminant hepatitis. In the study D-GaIN/LPS elevated serum GPTactivity that indicate a part...
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[Yogyakarta] : Universitas Gadjah Mada
2012
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| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | The objective of this study is to determine the hepatoprotective effect of GVT-O(one of curcumin analogues) against liver damage in rat-induced D-galactosamine (D-GaIN)/lipopolysaccharide (LPS) as a model of fulminant hepatitis. In the study D-GaIN/LPS elevated serum GPTactivity that indicate a particular occurrence of liver damage due to depletion of UTP and UDP-glucuronic acid. Administration of GVT-O(10 mg/kg) showed decreased enzyme activity of SGPT/SGOTbut had no effect on serum ALP and total bilirubin levels, whereas at doses of 20 and 40 mg/kg, the protective effect of GVT-Owas decrease. The glutathione content in the D-GaIN/LPS(0.76±0.07) mol!g liver content was found lower than controls (0.90 ± 0.03) mol!g liver. Administration of GVT-O dose of 10, 20 and 40 mg/kg restored glutathione content returned to normal leVels. The results showed that treatment of GVT-O showed nO/ieffecton TBARSand catalase activity. Treatment of D- GaIN/LPS, indicating the trend of increased TNF-a, although statistically not significant, while the administration of GVT-O showed a tendency to decrease the concentration of TNF-a. All findings of the results indicated that the GVT-Omainly lower dose (10 mg/kg) showed hepatoprotective action in rat model of fulminant hepatitis induced by D-GaIN/LPS.The results indicated that the mechanism of hepatoprotective effect of GVT-Ois not via antioxidant properties of GVT-O. However, further studies are necessary to explain the molecular mechanism of hepatoprotective effect of GVT-0. |
| first_indexed | 2024-03-13T19:09:44Z |
| format | Article |
| id | oai:generic.eprints.org:29156 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T19:09:44Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
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| spelling | oai:generic.eprints.org:291562014-06-18T00:23:06Z https://repository.ugm.ac.id/29156/ HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE Perpustakaan UGM, i-lib Jurnal i-lib UGM The objective of this study is to determine the hepatoprotective effect of GVT-O(one of curcumin analogues) against liver damage in rat-induced D-galactosamine (D-GaIN)/lipopolysaccharide (LPS) as a model of fulminant hepatitis. In the study D-GaIN/LPS elevated serum GPTactivity that indicate a particular occurrence of liver damage due to depletion of UTP and UDP-glucuronic acid. Administration of GVT-O(10 mg/kg) showed decreased enzyme activity of SGPT/SGOTbut had no effect on serum ALP and total bilirubin levels, whereas at doses of 20 and 40 mg/kg, the protective effect of GVT-Owas decrease. The glutathione content in the D-GaIN/LPS(0.76±0.07) mol!g liver content was found lower than controls (0.90 ± 0.03) mol!g liver. Administration of GVT-O dose of 10, 20 and 40 mg/kg restored glutathione content returned to normal leVels. The results showed that treatment of GVT-O showed nO/ieffecton TBARSand catalase activity. Treatment of D- GaIN/LPS, indicating the trend of increased TNF-a, although statistically not significant, while the administration of GVT-O showed a tendency to decrease the concentration of TNF-a. All findings of the results indicated that the GVT-Omainly lower dose (10 mg/kg) showed hepatoprotective action in rat model of fulminant hepatitis induced by D-GaIN/LPS.The results indicated that the mechanism of hepatoprotective effect of GVT-Ois not via antioxidant properties of GVT-O. However, further studies are necessary to explain the molecular mechanism of hepatoprotective effect of GVT-0. [Yogyakarta] : Universitas Gadjah Mada 2012 Article NonPeerReviewed Perpustakaan UGM, i-lib (2012) HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=12219 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE |
| title | HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE |
| title_full | HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE |
| title_fullStr | HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE |
| title_full_unstemmed | HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE |
| title_short | HEPATOPROTECTIVE EFFECTOF GAMAVUTON-O AGAINST D-GALACTOSAMINE/LIPOPOL YSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE |
| title_sort | hepatoprotective effectof gamavuton o against d galactosamine lipopol ysaccharide induced fulminant hepatic failure |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib hepatoprotectiveeffectofgamavutonoagainstdgalactosaminelipopolysaccharideinducedfulminanthepaticfailure |