Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is fo...
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| Format: | Article |
| Language: | English |
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Academic Journals
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/31142/1/JMPR_2013.pdf |
| _version_ | 1825647399554514944 |
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| author | Ghalib, Gaza Murad Mehdi, Sayed Hasan Hashim, Rokiah Sulaiman, Othman How, Fiona Ni Foong Ahamed, B. M. Khadeer Abdul Majid, Amin Malik Shah Ahmed, Faiyaz |
| author_facet | Ghalib, Gaza Murad Mehdi, Sayed Hasan Hashim, Rokiah Sulaiman, Othman How, Fiona Ni Foong Ahamed, B. M. Khadeer Abdul Majid, Amin Malik Shah Ahmed, Faiyaz |
| author_sort | Ghalib, Gaza Murad |
| collection | IIUM |
| description | 3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus
falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed
that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is found that
eupalitin induces the activation of caspases 3/7, a hallmark of apoptosis. The study suggests that the
anti-proliferative property of eupalitin towards the human colorectal tumor cells may be probably due to
its capability to induce apoptosis in cells. |
| first_indexed | 2024-03-05T23:17:02Z |
| format | Article |
| id | oai:generic.eprints.org:31142 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:17:02Z |
| publishDate | 2013 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | oai:generic.eprints.org:311422013-08-05T01:58:01Z http://irep.iium.edu.my/31142/ Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells Ghalib, Gaza Murad Mehdi, Sayed Hasan Hashim, Rokiah Sulaiman, Othman How, Fiona Ni Foong Ahamed, B. M. Khadeer Abdul Majid, Amin Malik Shah Ahmed, Faiyaz QD Chemistry 3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is found that eupalitin induces the activation of caspases 3/7, a hallmark of apoptosis. The study suggests that the anti-proliferative property of eupalitin towards the human colorectal tumor cells may be probably due to its capability to induce apoptosis in cells. Academic Journals 2013-05-25 Article PeerReviewed application/pdf en http://irep.iium.edu.my/31142/1/JMPR_2013.pdf Ghalib, Gaza Murad and Mehdi, Sayed Hasan and Hashim, Rokiah and Sulaiman, Othman and How, Fiona Ni Foong and Ahamed, B. M. Khadeer and Abdul Majid, Amin Malik Shah and Ahmed, Faiyaz (2013) Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells. Journal of Medicinal Plants Research, 7 (20). pp. 1401-1405. ISSN 1996-0875 http://www.academicjournals.org/JMPR/abstracts/abstracts/abstracts2013/25May/Ghalib%20et%20al.htm 10.5897/JMPR11.801 |
| spellingShingle | QD Chemistry Ghalib, Gaza Murad Mehdi, Sayed Hasan Hashim, Rokiah Sulaiman, Othman How, Fiona Ni Foong Ahamed, B. M. Khadeer Abdul Majid, Amin Malik Shah Ahmed, Faiyaz Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells |
| title | Eupalitin from Asparagus falcatus (Linn.) has anticancer
activity and induces activation of caspases 3/7
in human colorectal tumor cells |
| title_full | Eupalitin from Asparagus falcatus (Linn.) has anticancer
activity and induces activation of caspases 3/7
in human colorectal tumor cells |
| title_fullStr | Eupalitin from Asparagus falcatus (Linn.) has anticancer
activity and induces activation of caspases 3/7
in human colorectal tumor cells |
| title_full_unstemmed | Eupalitin from Asparagus falcatus (Linn.) has anticancer
activity and induces activation of caspases 3/7
in human colorectal tumor cells |
| title_short | Eupalitin from Asparagus falcatus (Linn.) has anticancer
activity and induces activation of caspases 3/7
in human colorectal tumor cells |
| title_sort | eupalitin from asparagus falcatus linn has anticancer activity and induces activation of caspases 3 7 in human colorectal tumor cells |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/31142/1/JMPR_2013.pdf |
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