SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES
Synthesis and activity test as deoxyribose degradation inhibitor of two asymmetric dibenzaiacetones have been conducted. The first compound, 1(E),4(E)-1-(4'- methoxyphenyl)-5-phenyl-1,4-pentadiene-3-one was synthesized from benzaidehyde, acetone and 4-ethoxybenzaidehyde. The second, 1(E),4(E)-1...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/32873/1/Prosiding_1.pdf |
| _version_ | 1797020188610134016 |
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| author | Handayani, Sri Matsjeh, Sabirin Anwar, Chairil Atun, Sri |
| author_facet | Handayani, Sri Matsjeh, Sabirin Anwar, Chairil Atun, Sri |
| author_sort | Handayani, Sri |
| collection | UGM |
| description | Synthesis and activity test as deoxyribose degradation inhibitor of two asymmetric dibenzaiacetones have been conducted. The first compound, 1(E),4(E)-1-(4'- methoxyphenyl)-5-phenyl-1,4-pentadiene-3-one was synthesized from benzaidehyde, acetone and 4-ethoxybenzaidehyde. The second, 1(E),4(E)-1-(3',4'-dimethoxyphenyl)-5-phenyl-1,4-pentadiene-3-one was from benzaidehyde, acetone and 3,4-dimethoxybenzaidehyde. Those compounds were synthesized by crossed aldol condensation in base condition with water-ethanol solvent. The swttrestze of both compounds using ice bath throughout the stirring. The precipitate was puotieebtitfcoloumn chromatography. Each product was characterized by FTIR, 1H-NMR, 13C-NMR, HMQC and HMBC. Activity test as deoxyribose degradation inhibitor showed ICso of both compounds are 1,7pM and 1,02 pM respectively. |
| first_indexed | 2024-03-13T19:12:08Z |
| format | Conference or Workshop Item |
| id | oai:generic.eprints.org:32873 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-13T19:12:08Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oai:generic.eprints.org:328732014-03-07T02:27:08Z https://repository.ugm.ac.id/32873/ SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES Handayani, Sri Matsjeh, Sabirin Anwar, Chairil Atun, Sri Makalah Seminar Synthesis and activity test as deoxyribose degradation inhibitor of two asymmetric dibenzaiacetones have been conducted. The first compound, 1(E),4(E)-1-(4'- methoxyphenyl)-5-phenyl-1,4-pentadiene-3-one was synthesized from benzaidehyde, acetone and 4-ethoxybenzaidehyde. The second, 1(E),4(E)-1-(3',4'-dimethoxyphenyl)-5-phenyl-1,4-pentadiene-3-one was from benzaidehyde, acetone and 3,4-dimethoxybenzaidehyde. Those compounds were synthesized by crossed aldol condensation in base condition with water-ethanol solvent. The swttrestze of both compounds using ice bath throughout the stirring. The precipitate was puotieebtitfcoloumn chromatography. Each product was characterized by FTIR, 1H-NMR, 13C-NMR, HMQC and HMBC. Activity test as deoxyribose degradation inhibitor showed ICso of both compounds are 1,7pM and 1,02 pM respectively. 2009-05-20 Conference or Workshop Item PeerReviewed application/pdf en https://repository.ugm.ac.id/32873/1/Prosiding_1.pdf Handayani, Sri and Matsjeh, Sabirin and Anwar, Chairil and Atun, Sri (2009) SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES. In: INTERNATIONAL CHEMISTRY SEMINAR, 20 May 2009, Yogyakarta. |
| spellingShingle | Makalah Seminar Handayani, Sri Matsjeh, Sabirin Anwar, Chairil Atun, Sri SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES |
| title | SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES |
| title_full | SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES |
| title_fullStr | SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES |
| title_full_unstemmed | SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES |
| title_short | SYNTHESIS AND ACTIVITY TEST AS DEOXYRIBOSE DEGRADATION INHIBITOR OF TWO ASYMMETRIC DIBENZALACETONES |
| title_sort | synthesis and activity test as deoxyribose degradation inhibitor of two asymmetric dibenzalacetones |
| topic | Makalah Seminar |
| url | https://repository.ugm.ac.id/32873/1/Prosiding_1.pdf |
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