Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study
Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine, International Islamic University Malaysia
2013
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| Online Access: | http://irep.iium.edu.my/33340/1/Vol12No2%2520Page%252003-10.pdf |
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| author | Al-Qaraghuli , Ahmed S Abdel Wahab, Emad M N Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi |
| author_facet | Al-Qaraghuli , Ahmed S Abdel Wahab, Emad M N Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi |
| author_sort | Al-Qaraghuli , Ahmed S |
| collection | IIUM |
| description | Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal
disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate
the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a
similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty
five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group)
was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II
(Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg
respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I.
Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group
IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats
from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour
after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed
multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated
rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion.
However, there was a faster and more complete healing process in the ranitidine treated group when compared
to the XSYWW treated subjects. |
| first_indexed | 2024-03-05T23:20:39Z |
| format | Article |
| id | oai:generic.eprints.org:33340 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:20:39Z |
| publishDate | 2013 |
| publisher | Faculty of Medicine, International Islamic University Malaysia |
| record_format | dspace |
| spelling | oai:generic.eprints.org:333402015-12-18T02:36:54Z http://irep.iium.edu.my/33340/ Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study Al-Qaraghuli , Ahmed S Abdel Wahab, Emad M N Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi QM Human anatomy QP Physiology RB Pathology RS Pharmacy and materia medica Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group) was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion. However, there was a faster and more complete healing process in the ranitidine treated group when compared to the XSYWW treated subjects. Faculty of Medicine, International Islamic University Malaysia 2013-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33340/1/Vol12No2%2520Page%252003-10.pdf Al-Qaraghuli , Ahmed S and Abdel Wahab, Emad M N and Al-Ani, Imad Matloub Dally and Faisal, Ghasak Ghazi (2013) Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study. International Medical Journal Malaysia, 12 (2). pp. 3-10. ISSN 1823-4631 http://www.e-imj.com/ |
| spellingShingle | QM Human anatomy QP Physiology RB Pathology RS Pharmacy and materia medica Al-Qaraghuli , Ahmed S Abdel Wahab, Emad M N Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study |
| title | Effects of Xiang Sha Yang Wei Wan on ethanol-induced
gastric ulcer in sprague dawley rats: A histological study |
| title_full | Effects of Xiang Sha Yang Wei Wan on ethanol-induced
gastric ulcer in sprague dawley rats: A histological study |
| title_fullStr | Effects of Xiang Sha Yang Wei Wan on ethanol-induced
gastric ulcer in sprague dawley rats: A histological study |
| title_full_unstemmed | Effects of Xiang Sha Yang Wei Wan on ethanol-induced
gastric ulcer in sprague dawley rats: A histological study |
| title_short | Effects of Xiang Sha Yang Wei Wan on ethanol-induced
gastric ulcer in sprague dawley rats: A histological study |
| title_sort | effects of xiang sha yang wei wan on ethanol induced gastric ulcer in sprague dawley rats a histological study |
| topic | QM Human anatomy QP Physiology RB Pathology RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/33340/1/Vol12No2%2520Page%252003-10.pdf |
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