Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis
The present study focuses on the bioassay guided isolation of antimicrobial compounds from Artocarpus altilis. The hexane, dichloromethane and methanol extracts were obtained from the dried (twigs of A. altilis) by using Soxhlet extraction. The plant crude extracts were evaluated for in vitro antimi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Merit Research Journal
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/33451/1/Artocarpus_altilis_MRJEST.pdf |
| _version_ | 1796878389667168256 |
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| author | Omar, Muhammad Nor Zuberdi, Ahmad Muzammil Khan, Naik T. Abdul Aziz, Muhammad Zahid Kamal, Tara |
| author_facet | Omar, Muhammad Nor Zuberdi, Ahmad Muzammil Khan, Naik T. Abdul Aziz, Muhammad Zahid Kamal, Tara |
| author_sort | Omar, Muhammad Nor |
| collection | IIUM |
| description | The present study focuses on the bioassay guided isolation of antimicrobial compounds from Artocarpus altilis. The hexane, dichloromethane and methanol extracts were obtained from the dried (twigs of A. altilis) by using Soxhlet extraction. The plant crude extracts were evaluated for in vitro antimicrobial and antioxidant activities revealed that twigs part of A. altilis had potent antimicrobial activities, further purification had been done through column chromatography(CC) of dichloromethane and hexane extracts of A. altilis, which were afforded stigmasterol and cycloartenyl acetate respectively, the two compounds exhibited in vitro antimicrobial activity against S. aureus value of (11±0.5mm) and (11.3±0.5mm). Whereas minimum inhibition concetration (MIC) and minimum bactericidal/minimum fungicidal concetration (MBC/MFC) for isolated compounds were ranged from 62.5-500 µg/ml. Their structures were identified by 1H-NMR, 13C-NMR, IR and the spectra obtained were compared with previous data. This study forms a strong basis for declaring A. altilis as antimicrobial potential source to treat pathogenic microorganisms. |
| first_indexed | 2024-03-05T23:20:51Z |
| format | Article |
| id | oai:generic.eprints.org:33451 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:20:51Z |
| publishDate | 2013 |
| publisher | Merit Research Journal |
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| spelling | oai:generic.eprints.org:334512013-12-16T01:37:42Z http://irep.iium.edu.my/33451/ Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis Omar, Muhammad Nor Zuberdi, Ahmad Muzammil Khan, Naik T. Abdul Aziz, Muhammad Zahid Kamal, Tara QD Chemistry The present study focuses on the bioassay guided isolation of antimicrobial compounds from Artocarpus altilis. The hexane, dichloromethane and methanol extracts were obtained from the dried (twigs of A. altilis) by using Soxhlet extraction. The plant crude extracts were evaluated for in vitro antimicrobial and antioxidant activities revealed that twigs part of A. altilis had potent antimicrobial activities, further purification had been done through column chromatography(CC) of dichloromethane and hexane extracts of A. altilis, which were afforded stigmasterol and cycloartenyl acetate respectively, the two compounds exhibited in vitro antimicrobial activity against S. aureus value of (11±0.5mm) and (11.3±0.5mm). Whereas minimum inhibition concetration (MIC) and minimum bactericidal/minimum fungicidal concetration (MBC/MFC) for isolated compounds were ranged from 62.5-500 µg/ml. Their structures were identified by 1H-NMR, 13C-NMR, IR and the spectra obtained were compared with previous data. This study forms a strong basis for declaring A. altilis as antimicrobial potential source to treat pathogenic microorganisms. Merit Research Journal 2013-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33451/1/Artocarpus_altilis_MRJEST.pdf Omar, Muhammad Nor and Zuberdi, Ahmad Muzammil and Khan, Naik T. and Abdul Aziz, Muhammad Zahid and Kamal, Tara (2013) Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis. Merit Research Journal of Environmental Science and Toxicology, 1 (8). pp. 147-155. ISSN 2350-2266 http://www.meritresearchjournals.org/est/index.htm |
| spellingShingle | QD Chemistry Omar, Muhammad Nor Zuberdi, Ahmad Muzammil Khan, Naik T. Abdul Aziz, Muhammad Zahid Kamal, Tara Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis |
| title | Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis |
| title_full | Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis |
| title_fullStr | Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis |
| title_full_unstemmed | Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis |
| title_short | Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis |
| title_sort | isolation and identification of bioactive compounds from twigs of artocarpus altilis |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/33451/1/Artocarpus_altilis_MRJEST.pdf |
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