Mesenchymal stem cell therapy for injured growth plate
The growth plate has a limited self-healing capacity. Fractures sustained to the growth plate of young children could cause growth disturbances like angular deformity or growth arrest. Established therapies for injured physis only address related complications. Mesenchymal stem cells (MSCs) are mult...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
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Frontiers in Bioscience
2013
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| Online Access: | http://irep.iium.edu.my/34237/1/Frontiers_in_Bioscience_S5-article.docx http://irep.iium.edu.my/34237/2/Mesenchymal_stem_cell_therapy_for_injured_growth_plate.pdf |
| _version_ | 1796878487382917120 |
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| author | Awang, Mohd Shukrimi Mohd, Afizah Jacqueline F , Schmitt James, Hui |
| author_facet | Awang, Mohd Shukrimi Mohd, Afizah Jacqueline F , Schmitt James, Hui |
| author_sort | Awang, Mohd Shukrimi |
| collection | IIUM |
| description | The growth plate has a limited self-healing capacity. Fractures sustained to the growth plate of young children could cause growth disturbances like angular deformity or growth arrest. Established therapies for injured physis only address related complications. Mesenchymal stem cells (MSCs) are multipotent cells which are capable of differentiating into various cells of the musculoskeletal system. Various MSC types have been tested for physeal regeneration, through in vivo lapine, porcine and ovine models, for the duration of 4-16 weeks. The created defect sizes ranged from 7-50% of the growth plate area, to simulate clinically-encountered cases. In vitro models have also been investigated, as a means to screen potential treatments. The effects of MSCs gathered from these models have revealed its function in the prevention of bone bridge formation, with the subsequent development of organized physeal repair tissue. Possible influential factors like the number of implanted MSCs, preconditioned state, growth factors, chondrocyte-MSC interaction and scaffolds are discussed. Possible further studies to optimize physeal repair based on MSC therapy in articular cartilage are also included. |
| first_indexed | 2024-03-05T23:22:12Z |
| format | Article |
| id | oai:generic.eprints.org:34237 |
| institution | International Islamic University Malaysia |
| language | English English |
| last_indexed | 2024-03-05T23:22:12Z |
| publishDate | 2013 |
| publisher | Frontiers in Bioscience |
| record_format | dspace |
| spelling | oai:generic.eprints.org:342372014-01-16T09:30:52Z http://irep.iium.edu.my/34237/ Mesenchymal stem cell therapy for injured growth plate Awang, Mohd Shukrimi Mohd, Afizah Jacqueline F , Schmitt James, Hui RJ Pediatrics The growth plate has a limited self-healing capacity. Fractures sustained to the growth plate of young children could cause growth disturbances like angular deformity or growth arrest. Established therapies for injured physis only address related complications. Mesenchymal stem cells (MSCs) are multipotent cells which are capable of differentiating into various cells of the musculoskeletal system. Various MSC types have been tested for physeal regeneration, through in vivo lapine, porcine and ovine models, for the duration of 4-16 weeks. The created defect sizes ranged from 7-50% of the growth plate area, to simulate clinically-encountered cases. In vitro models have also been investigated, as a means to screen potential treatments. The effects of MSCs gathered from these models have revealed its function in the prevention of bone bridge formation, with the subsequent development of organized physeal repair tissue. Possible influential factors like the number of implanted MSCs, preconditioned state, growth factors, chondrocyte-MSC interaction and scaffolds are discussed. Possible further studies to optimize physeal repair based on MSC therapy in articular cartilage are also included. Frontiers in Bioscience 2013-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/34237/1/Frontiers_in_Bioscience_S5-article.docx application/pdf en http://irep.iium.edu.my/34237/2/Mesenchymal_stem_cell_therapy_for_injured_growth_plate.pdf Awang, Mohd Shukrimi and Mohd, Afizah and Jacqueline F , Schmitt and James, Hui (2013) Mesenchymal stem cell therapy for injured growth plate. Frontiers in Bioscience Scholar Edition, S5 (3). pp. 774-785. ISSN 1945-0516 http://www.bioscience.org/2013/v5s/af/407/3.htm http://dx.doi.org/10.2741/S407 |
| spellingShingle | RJ Pediatrics Awang, Mohd Shukrimi Mohd, Afizah Jacqueline F , Schmitt James, Hui Mesenchymal stem cell therapy for injured growth plate |
| title | Mesenchymal stem cell therapy for injured growth plate |
| title_full | Mesenchymal stem cell therapy for injured growth plate |
| title_fullStr | Mesenchymal stem cell therapy for injured growth plate |
| title_full_unstemmed | Mesenchymal stem cell therapy for injured growth plate |
| title_short | Mesenchymal stem cell therapy for injured growth plate |
| title_sort | mesenchymal stem cell therapy for injured growth plate |
| topic | RJ Pediatrics |
| url | http://irep.iium.edu.my/34237/1/Frontiers_in_Bioscience_S5-article.docx http://irep.iium.edu.my/34237/2/Mesenchymal_stem_cell_therapy_for_injured_growth_plate.pdf |
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