Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience
Background and Objective: Intravenous thrombolysis service for stroke was introduced at the Universiti Kebangsaan Malaysia Medical Centre (UKMMC) in 2009, based on the recommendations of a multidisciplinary team of clinicians. We report the experience at our center in establishing a stroke protocol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Neurology Asia
2013
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| Online Access: | http://irep.iium.edu.my/34795/1/neuroasia-2013-18%284%29-355.pdf |
| _version_ | 1825647810246082560 |
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| author | hashim, hilwati Hassan, Radhiana Sharis Osman, Syazarina Muda, Ahmad Sobri |
| author_facet | hashim, hilwati Hassan, Radhiana Sharis Osman, Syazarina Muda, Ahmad Sobri |
| author_sort | hashim, hilwati |
| collection | IIUM |
| description | Background and Objective: Intravenous thrombolysis service for stroke was introduced at the Universiti Kebangsaan Malaysia Medical Centre (UKMMC) in 2009, based on the recommendations of a multidisciplinary team of clinicians. We report the experience at our center in establishing a stroke protocol incorporating computed tomography perfusion (CTP) of the brain, to assess the feasibility of incorporating CTP in the stroke protocol.
Methods: A retrospective review of all patients who had a CTP between January 2010 and December 2011 was performed. Results: Of 272 patients who were admitted with acute ischemic stroke, 44 (16.2%) arrived within 4.5 hours from symptom onset and had a CTP performed with the intention to treat. The median time for symptom-to-door, symptom-to-scan and door-to-scan was 90.0 minutes (62.5 – 146.3), 211.0 minutes (165.5 – 273.5) and 85.0 minutes (48.0 – 144.8) respectively. Eight patients (2.9%) were thrombolysed of whom five received IV thrombolysis and three underwent mechanical thrombolysis. The median symptom-to-needle and door-to-needle times were 290.5 minutes (261.3 – 405.0) and 225.0 minutes (172.5 – 316.8) respectively. Four patients were thrombolysed despite being outside the window of treatment based on the CTP findings. Six of the thrombolysed patients had a Modified Rankin Score (MRS) of 1-2 at 5 months post procedure.
Conclusions: CTP provides a benefit to management decisions and subsequent patient outcome. It is feasible to incorporate CTP as a standard imaging modality in a stroke protocol. The delays in the time-dependent pathways are due to our work flow and organisational process rather than performing the CTP per se. |
| first_indexed | 2024-03-05T23:23:05Z |
| format | Article |
| id | oai:generic.eprints.org:34795 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:23:05Z |
| publishDate | 2013 |
| publisher | Neurology Asia |
| record_format | dspace |
| spelling | oai:generic.eprints.org:347952014-01-23T00:54:25Z http://irep.iium.edu.my/34795/ Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience hashim, hilwati Hassan, Radhiana Sharis Osman, Syazarina Muda, Ahmad Sobri R Medicine (General) Background and Objective: Intravenous thrombolysis service for stroke was introduced at the Universiti Kebangsaan Malaysia Medical Centre (UKMMC) in 2009, based on the recommendations of a multidisciplinary team of clinicians. We report the experience at our center in establishing a stroke protocol incorporating computed tomography perfusion (CTP) of the brain, to assess the feasibility of incorporating CTP in the stroke protocol. Methods: A retrospective review of all patients who had a CTP between January 2010 and December 2011 was performed. Results: Of 272 patients who were admitted with acute ischemic stroke, 44 (16.2%) arrived within 4.5 hours from symptom onset and had a CTP performed with the intention to treat. The median time for symptom-to-door, symptom-to-scan and door-to-scan was 90.0 minutes (62.5 – 146.3), 211.0 minutes (165.5 – 273.5) and 85.0 minutes (48.0 – 144.8) respectively. Eight patients (2.9%) were thrombolysed of whom five received IV thrombolysis and three underwent mechanical thrombolysis. The median symptom-to-needle and door-to-needle times were 290.5 minutes (261.3 – 405.0) and 225.0 minutes (172.5 – 316.8) respectively. Four patients were thrombolysed despite being outside the window of treatment based on the CTP findings. Six of the thrombolysed patients had a Modified Rankin Score (MRS) of 1-2 at 5 months post procedure. Conclusions: CTP provides a benefit to management decisions and subsequent patient outcome. It is feasible to incorporate CTP as a standard imaging modality in a stroke protocol. The delays in the time-dependent pathways are due to our work flow and organisational process rather than performing the CTP per se. Neurology Asia 2013-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/34795/1/neuroasia-2013-18%284%29-355.pdf hashim, hilwati and Hassan, Radhiana and Sharis Osman, Syazarina and Muda, Ahmad Sobri (2013) Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience. Neurology Asia, 18 (4). pp. 355-360. ISSN 1823-6138 http://www.neurology-asia.org/ |
| spellingShingle | R Medicine (General) hashim, hilwati Hassan, Radhiana Sharis Osman, Syazarina Muda, Ahmad Sobri Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience |
| title | Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience |
| title_full | Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience |
| title_fullStr | Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience |
| title_full_unstemmed | Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience |
| title_short | Evaluation of time-dependent pathways in an acute ischemic stroke protocol that incorporates CT perfusion: A tertiary referral center experience |
| title_sort | evaluation of time dependent pathways in an acute ischemic stroke protocol that incorporates ct perfusion a tertiary referral center experience |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/34795/1/neuroasia-2013-18%284%29-355.pdf |
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