Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)
Wolfram syndrome (WFS) is a rare neurodegerative disorder which is characterized by presentation of diabetes insipidus, juvenile diabetes mellitus, optic atrophy and deafness. We describe a case of WFS with presentation of psychosis. A 17-year-old female presented with psychiatric manifestations, n...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Malaysian Journal of Psychiatry
2014
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| Online Access: | http://irep.iium.edu.my/35602/1/43.Wolfran_Syndrome.pdf |
| _version_ | 1825647893809201152 |
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| author | Musa, Ramli NNA, Fatnoon |
| author_facet | Musa, Ramli NNA, Fatnoon |
| author_sort | Musa, Ramli |
| collection | IIUM |
| description | Wolfram syndrome (WFS) is a rare neurodegerative disorder which is characterized by presentation of diabetes insipidus, juvenile diabetes mellitus, optic atrophy and deafness. We describe a case of WFS with presentation of psychosis. A 17-year-old female presented with psychiatric
manifestations, namely inappropriate behaviour and second person auditory hallucination since the age of 16 years. The patient was diagnosed with type 1 diabetes mellitus at the age of 10 years old and subsequently progressive
hearing and visual loss a year later. Her ophthalmic evaluation revealed total blindness due to optic atrophy. However she did not have renal dysfunction and diabetes insipidus which are also features of the syndrome. There is scarce literature to describe on psychiatric presentation in WFS. In the past,the psychiatric manifestation which was reported most of times was mood and suicidal behaviour. Hardly any article reported about psychosis (hallucination). We believe, her psychiatric manifestations were related to sensory deprivation due to blindness and deafness caused by the progression
of WFS. |
| first_indexed | 2024-03-05T23:24:18Z |
| format | Article |
| id | oai:generic.eprints.org:35602 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:24:18Z |
| publishDate | 2014 |
| publisher | Malaysian Journal of Psychiatry |
| record_format | dspace |
| spelling | oai:generic.eprints.org:356022014-02-20T04:02:46Z http://irep.iium.edu.my/35602/ Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD) Musa, Ramli NNA, Fatnoon RC321 Neuroscience. Biological psychiatry. Neuropsychiatry Wolfram syndrome (WFS) is a rare neurodegerative disorder which is characterized by presentation of diabetes insipidus, juvenile diabetes mellitus, optic atrophy and deafness. We describe a case of WFS with presentation of psychosis. A 17-year-old female presented with psychiatric manifestations, namely inappropriate behaviour and second person auditory hallucination since the age of 16 years. The patient was diagnosed with type 1 diabetes mellitus at the age of 10 years old and subsequently progressive hearing and visual loss a year later. Her ophthalmic evaluation revealed total blindness due to optic atrophy. However she did not have renal dysfunction and diabetes insipidus which are also features of the syndrome. There is scarce literature to describe on psychiatric presentation in WFS. In the past,the psychiatric manifestation which was reported most of times was mood and suicidal behaviour. Hardly any article reported about psychosis (hallucination). We believe, her psychiatric manifestations were related to sensory deprivation due to blindness and deafness caused by the progression of WFS. Malaysian Journal of Psychiatry 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/35602/1/43.Wolfran_Syndrome.pdf Musa, Ramli and NNA, Fatnoon (2014) Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD). Malaysian Journal of Psychiatry, 23 (1). ISSN 0128-8628 http://www.mjpsychiatry.org/index.php/mjp/article/view/281 |
| spellingShingle | RC321 Neuroscience. Biological psychiatry. Neuropsychiatry Musa, Ramli NNA, Fatnoon Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD) |
| title | Psychotic manifestation in a patient with Wolfram syndrome
(DIDMOAD) |
| title_full | Psychotic manifestation in a patient with Wolfram syndrome
(DIDMOAD) |
| title_fullStr | Psychotic manifestation in a patient with Wolfram syndrome
(DIDMOAD) |
| title_full_unstemmed | Psychotic manifestation in a patient with Wolfram syndrome
(DIDMOAD) |
| title_short | Psychotic manifestation in a patient with Wolfram syndrome
(DIDMOAD) |
| title_sort | psychotic manifestation in a patient with wolfram syndrome didmoad |
| topic | RC321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| url | http://irep.iium.edu.my/35602/1/43.Wolfran_Syndrome.pdf |
| work_keys_str_mv | AT musaramli psychoticmanifestationinapatientwithwolframsyndromedidmoad AT nnafatnoon psychoticmanifestationinapatientwithwolframsyndromedidmoad |