The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension
Normotensive subjects with family history of hypertension (FHT) have been reported to have increased left ventricular mass index and reduced ventricular compliance. Of interest is whether blood pressure variability (BPV), which has been associated with target organ damage, is then part of this...
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| Format: | Article |
| Language: | English |
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Malaysian Medical Associations
2008
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| Online Access: | http://irep.iium.edu.my/363/1/Hypertension.pdf |
| _version_ | 1825644049804034048 |
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| author | Mokhtar, Rafidah Hanim Ayob, Azizi Hashim, Suhaimi Mohd. Noor, Noriah |
| author_facet | Mokhtar, Rafidah Hanim Ayob, Azizi Hashim, Suhaimi Mohd. Noor, Noriah |
| author_sort | Mokhtar, Rafidah Hanim |
| collection | IIUM |
| description | Normotensive subjects with family history of hypertension
(FHT) have been reported to have increased left ventricular
mass index and reduced ventricular compliance. Of interest
is whether blood pressure variability (BPV), which has been
associated with target organ damage, is then part of this
complex inherited syndrome? The objectives of this study
are to determine whether there are any significant
differences in BPV, arterial compliance and humoral factors in subjects with FHT as compared to controls. Thirty-five
subjects with self reported FHT and 35 matched controls
underwent 24 hour BP monitoring (BR-102, Schiller Inc.
Germany). Arterial compliance was measured using systolic
pulse wave tonometry (HDI/Pulsewave Cardiovascular
Profiling Instrument, Hypertension Diagnostic Inc. USA).
None of the subjects were hypertensive or diabetic. Out of
these numbers, 25 subjects with FHT and 26 controls had
measurements of plasma catecholamines, plasma renin and
serum aldosterone. Catecholamines were assayed with high
performance liquid chromatography, while both renin and
aldosterone measurements were by radioimmunoassay.
Subjects with FHT have higher night time BPV. There was no
significant difference in arterial compliances between both
groups. There were increased level of norepinephrine (NE) in
subjects with FHT but epinephrine (E), renin and aldosterone
levels were similar in both groups. There were no
correlations between NE and BPV but E was negatively
associated with daytime and mean arterial systolic BPV. In
conclusion subjects with FHT demonstrated a higher night
time BPV and NE level as compared to controls. |
| first_indexed | 2024-03-05T22:27:36Z |
| format | Article |
| id | oai:generic.eprints.org:363 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:27:36Z |
| publishDate | 2008 |
| publisher | Malaysian Medical Associations |
| record_format | dspace |
| spelling | oai:generic.eprints.org:3632017-06-16T02:03:53Z http://irep.iium.edu.my/363/ The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension Mokhtar, Rafidah Hanim Ayob, Azizi Hashim, Suhaimi Mohd. Noor, Noriah R Medicine (General) RM Therapeutics. Pharmacology Normotensive subjects with family history of hypertension (FHT) have been reported to have increased left ventricular mass index and reduced ventricular compliance. Of interest is whether blood pressure variability (BPV), which has been associated with target organ damage, is then part of this complex inherited syndrome? The objectives of this study are to determine whether there are any significant differences in BPV, arterial compliance and humoral factors in subjects with FHT as compared to controls. Thirty-five subjects with self reported FHT and 35 matched controls underwent 24 hour BP monitoring (BR-102, Schiller Inc. Germany). Arterial compliance was measured using systolic pulse wave tonometry (HDI/Pulsewave Cardiovascular Profiling Instrument, Hypertension Diagnostic Inc. USA). None of the subjects were hypertensive or diabetic. Out of these numbers, 25 subjects with FHT and 26 controls had measurements of plasma catecholamines, plasma renin and serum aldosterone. Catecholamines were assayed with high performance liquid chromatography, while both renin and aldosterone measurements were by radioimmunoassay. Subjects with FHT have higher night time BPV. There was no significant difference in arterial compliances between both groups. There were increased level of norepinephrine (NE) in subjects with FHT but epinephrine (E), renin and aldosterone levels were similar in both groups. There were no correlations between NE and BPV but E was negatively associated with daytime and mean arterial systolic BPV. In conclusion subjects with FHT demonstrated a higher night time BPV and NE level as compared to controls. Malaysian Medical Associations 2008-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/363/1/Hypertension.pdf Mokhtar, Rafidah Hanim and Ayob, Azizi and Hashim, Suhaimi and Mohd. Noor, Noriah (2008) The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension. Medical Journal of Malaysia, 63 (1). pp. 9-16. ISSN 0300-5283 http://www.e-mjm.org/2008/v63n1/Hypertension.pdf |
| spellingShingle | R Medicine (General) RM Therapeutics. Pharmacology Mokhtar, Rafidah Hanim Ayob, Azizi Hashim, Suhaimi Mohd. Noor, Noriah The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension |
| title | The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension |
| title_full | The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension |
| title_fullStr | The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension |
| title_full_unstemmed | The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension |
| title_short | The blood pressure variability, arterial elasticity and humoral factors in subjects with family history of hypertension |
| title_sort | blood pressure variability arterial elasticity and humoral factors in subjects with family history of hypertension |
| topic | R Medicine (General) RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/363/1/Hypertension.pdf |
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