QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists
Flavonoids are natural inhibitors against platelet activating factor (PAF) receptor. PAF is involved in several patho-physiological conditions such as inflammation, atherosclerosis, asthma and thrombosis. The PAF actions can be inhibited by blocking its receptor with an antagonist. The aim of this...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
AENSI Publications
2014
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/36396/1/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating.pdf http://irep.iium.edu.my/36396/2/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating_SCOPUS.pdf |
| _version_ | 1796878738488557568 |
|---|---|
| author | Abdullah, Nor Hayati Kiong, Ling Sui Noorbatcha, Ibrahim Ali |
| author_facet | Abdullah, Nor Hayati Kiong, Ling Sui Noorbatcha, Ibrahim Ali |
| author_sort | Abdullah, Nor Hayati |
| collection | IIUM |
| description | Flavonoids are natural inhibitors against platelet activating factor (PAF) receptor. PAF is involved in several patho-physiological conditions such as inflammation,
atherosclerosis, asthma and thrombosis. The PAF actions can be inhibited by blocking its receptor with an antagonist. The aim of this study was to find the structure activity
relationship between the PAF receptor binding antagonist activity and the structure based properties of flavonoids 1-11 by using quantum chemical quantitative structure
activity relationship (QSAR) approach. The semi-empirical quantum chemical method was used to optimize the molecular structures of the flavanoids and various quantum chemical descriptors were calculated from the optimized structures. Heuristic and multi-linear regression methods were used to determine the correlation between the quantum chemical properties and the experimental PAF receptor binding inhibitory activity. The best correlation equation was obtained using multi-linear correlation method with three descriptors and correlation coefficient, R2= 0.9632 |
| first_indexed | 2024-03-05T23:25:47Z |
| format | Article |
| id | oai:generic.eprints.org:36396 |
| institution | International Islamic University Malaysia |
| language | English English |
| last_indexed | 2024-03-05T23:25:47Z |
| publishDate | 2014 |
| publisher | AENSI Publications |
| record_format | dspace |
| spelling | oai:generic.eprints.org:363962020-11-02T01:41:20Z http://irep.iium.edu.my/36396/ QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists Abdullah, Nor Hayati Kiong, Ling Sui Noorbatcha, Ibrahim Ali TP Chemical technology TP248.13 Biotechnology Flavonoids are natural inhibitors against platelet activating factor (PAF) receptor. PAF is involved in several patho-physiological conditions such as inflammation, atherosclerosis, asthma and thrombosis. The PAF actions can be inhibited by blocking its receptor with an antagonist. The aim of this study was to find the structure activity relationship between the PAF receptor binding antagonist activity and the structure based properties of flavonoids 1-11 by using quantum chemical quantitative structure activity relationship (QSAR) approach. The semi-empirical quantum chemical method was used to optimize the molecular structures of the flavanoids and various quantum chemical descriptors were calculated from the optimized structures. Heuristic and multi-linear regression methods were used to determine the correlation between the quantum chemical properties and the experimental PAF receptor binding inhibitory activity. The best correlation equation was obtained using multi-linear correlation method with three descriptors and correlation coefficient, R2= 0.9632 AENSI Publications 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/36396/1/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating.pdf application/pdf en http://irep.iium.edu.my/36396/2/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating_SCOPUS.pdf Abdullah, Nor Hayati and Kiong, Ling Sui and Noorbatcha, Ibrahim Ali (2014) QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists. Advances in Environmental Biology, 8 (3 (special)). pp. 797-802. ISSN 1995-0756 http://www.aensiweb.com/aeb_Special_2014.html |
| spellingShingle | TP Chemical technology TP248.13 Biotechnology Abdullah, Nor Hayati Kiong, Ling Sui Noorbatcha, Ibrahim Ali QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists |
| title | QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists |
| title_full | QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists |
| title_fullStr | QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists |
| title_full_unstemmed | QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists |
| title_short | QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists |
| title_sort | qsar study of flavonoids as platelet activating factor paf receptor binding antagonists |
| topic | TP Chemical technology TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/36396/1/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating.pdf http://irep.iium.edu.my/36396/2/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating_SCOPUS.pdf |
| work_keys_str_mv | AT abdullahnorhayati qsarstudyofflavonoidsasplateletactivatingfactorpafreceptorbindingantagonists AT kionglingsui qsarstudyofflavonoidsasplateletactivatingfactorpafreceptorbindingantagonists AT noorbatchaibrahimali qsarstudyofflavonoidsasplateletactivatingfactorpafreceptorbindingantagonists |