Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion
A number of antihypertensive drugs are known to be diabetogenic. This may contribute to less than expected decrease in the incidence of coronary heart disease with reduction in blood pressure with treatment in hypertensive patients. This study was aimed to determine the effects of a member, Valsarta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Islamic World Academy of Sciences
2006
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| Online Access: | http://irep.iium.edu.my/399/1/Medical_Journal_of_Islamic_World_Academy_of_Sciences.pdf |
| _version_ | 1825644053880897536 |
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| author | Ayob, Azizi Hashim, Suhaimi Azdan, Zulnizam Abdul Razak, Tariq |
| author_facet | Ayob, Azizi Hashim, Suhaimi Azdan, Zulnizam Abdul Razak, Tariq |
| author_sort | Ayob, Azizi |
| collection | IIUM |
| description | A number of antihypertensive drugs are known to be diabetogenic. This may contribute to less than expected decrease in the incidence of coronary heart disease with reduction in blood pressure with treatment in hypertensive patients. This study was aimed to determine the effects of a member, Valsartan, of a new class of drugs, angiotensin II receptor blocker, on glucose induced insulin secretion. Male albino rat pancreases were used. The isolated ancreases were perfused with Kreb's solution containing bovine albumin (200 mg/dl) with low glucose (60 mg/dl) followed by high glucose (300 mg/dl) at a rate of 4 ml/min. The dose of Valsartan used was based on the peak plasma level achieved in human at standard single oral dose of 80 mg daily, which was 1.64 mg/L. Five treatment groups were used: Control group, Valsartan at 10%, Valsartan at 100% and Valsartan at 10 times of the 1.64 mg/L, and Diazoxide 10 μg/ml group. Insulin levels in the perfusate were measured by radioimmunoassay. Valsartan at all concentrations significantly increases glucose induced insulin secretion (p < 0.05). Valsartan at 10 %, Valsartan at 100% and Valsartan at 10 times of the 16.4 mg/L, increases glucose induced insulin secretion by 226.4 %, 161.7 % and 156.3 %, respectively. Diazoxide, significantly
inhibits glucose induced insulin secretion (p < 0.05).
Valsartan at all concentrations enhances glucose-induced insulin secretion in isolated rat pancreas technique. |
| first_indexed | 2024-03-05T22:27:39Z |
| format | Article |
| id | oai:generic.eprints.org:399 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:27:39Z |
| publishDate | 2006 |
| publisher | Islamic World Academy of Sciences |
| record_format | dspace |
| spelling | oai:generic.eprints.org:3992016-11-12T04:50:58Z http://irep.iium.edu.my/399/ Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion Ayob, Azizi Hashim, Suhaimi Azdan, Zulnizam Abdul Razak, Tariq RM Therapeutics. Pharmacology A number of antihypertensive drugs are known to be diabetogenic. This may contribute to less than expected decrease in the incidence of coronary heart disease with reduction in blood pressure with treatment in hypertensive patients. This study was aimed to determine the effects of a member, Valsartan, of a new class of drugs, angiotensin II receptor blocker, on glucose induced insulin secretion. Male albino rat pancreases were used. The isolated ancreases were perfused with Kreb's solution containing bovine albumin (200 mg/dl) with low glucose (60 mg/dl) followed by high glucose (300 mg/dl) at a rate of 4 ml/min. The dose of Valsartan used was based on the peak plasma level achieved in human at standard single oral dose of 80 mg daily, which was 1.64 mg/L. Five treatment groups were used: Control group, Valsartan at 10%, Valsartan at 100% and Valsartan at 10 times of the 1.64 mg/L, and Diazoxide 10 μg/ml group. Insulin levels in the perfusate were measured by radioimmunoassay. Valsartan at all concentrations significantly increases glucose induced insulin secretion (p < 0.05). Valsartan at 10 %, Valsartan at 100% and Valsartan at 10 times of the 16.4 mg/L, increases glucose induced insulin secretion by 226.4 %, 161.7 % and 156.3 %, respectively. Diazoxide, significantly inhibits glucose induced insulin secretion (p < 0.05). Valsartan at all concentrations enhances glucose-induced insulin secretion in isolated rat pancreas technique. Islamic World Academy of Sciences 2006-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/399/1/Medical_Journal_of_Islamic_World_Academy_of_Sciences.pdf Ayob, Azizi and Hashim, Suhaimi and Azdan, Zulnizam and Abdul Razak, Tariq (2006) Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion. Medical Journal of Islamic World Academy of Sciences, 16 (1). pp. 11-17. ISSN 1016-3360 http://www.medicaljournal-ias.org/tr/Icerik.aspx?IcerikID=124 |
| spellingShingle | RM Therapeutics. Pharmacology Ayob, Azizi Hashim, Suhaimi Azdan, Zulnizam Abdul Razak, Tariq Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion |
| title | Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion |
| title_full | Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion |
| title_fullStr | Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion |
| title_full_unstemmed | Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion |
| title_short | Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion |
| title_sort | angiotensin ii receptor blocker valsartan enhances glucose induced insulin secretion |
| topic | RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/399/1/Medical_Journal_of_Islamic_World_Academy_of_Sciences.pdf |
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