In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)
Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. Th...
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| Format: | Article |
| Language: | English |
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Universiti Teknologi Malaysia
2015
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| Online Access: | http://irep.iium.edu.my/47438/1/5994-16777-1-SM.pdf |
| _version_ | 1825649312322813952 |
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| author | Mohd Shafri, Mohd Affendi Yusof, Fathin Athirah Md Zain, Ahmad Zulkarami |
| author_facet | Mohd Shafri, Mohd Affendi Yusof, Fathin Athirah Md Zain, Ahmad Zulkarami |
| author_sort | Mohd Shafri, Mohd Affendi |
| collection | IIUM |
| description | Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. The mixtures were then filtered, concentrated and dried. The cytotoxicity of extracts on an osteosarcoma cell line, HOS CRL, was determined using MTT assay method. The results were analysed with Tukey’s test (p<0.05) showed that F. assafoetida extract has cytotoxic effect which is dependent on the type of solvent (methanol > ethanol) and concentration (higher methanolic content > lower methanolic content). In conclusion, extracts of Ferula assafoetida might possess cytotoxic activity which could be useful to be developed for an anti-cancer treatment.
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| first_indexed | 2024-03-05T23:45:45Z |
| format | Article |
| id | oai:generic.eprints.org:47438 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:45:45Z |
| publishDate | 2015 |
| publisher | Universiti Teknologi Malaysia |
| record_format | dspace |
| spelling | oai:generic.eprints.org:474382016-07-15T02:14:13Z http://irep.iium.edu.my/47438/ In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl) Mohd Shafri, Mohd Affendi Yusof, Fathin Athirah Md Zain, Ahmad Zulkarami Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. The mixtures were then filtered, concentrated and dried. The cytotoxicity of extracts on an osteosarcoma cell line, HOS CRL, was determined using MTT assay method. The results were analysed with Tukey’s test (p<0.05) showed that F. assafoetida extract has cytotoxic effect which is dependent on the type of solvent (methanol > ethanol) and concentration (higher methanolic content > lower methanolic content). In conclusion, extracts of Ferula assafoetida might possess cytotoxic activity which could be useful to be developed for an anti-cancer treatment. Universiti Teknologi Malaysia 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47438/1/5994-16777-1-SM.pdf Mohd Shafri, Mohd Affendi and Yusof, Fathin Athirah and Md Zain, Ahmad Zulkarami (2015) In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl). Jurnal Teknologi, 77 (3). pp. 7-11. ISSN 0127–9696 E-ISSN 2180–3722 http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/5994 http://dx.doi.org/10.11113/jt.v77.5994 |
| spellingShingle | Mohd Shafri, Mohd Affendi Yusof, Fathin Athirah Md Zain, Ahmad Zulkarami In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl) |
| title | In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl) |
| title_full | In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl) |
| title_fullStr | In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl) |
| title_full_unstemmed | In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl) |
| title_short | In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl) |
| title_sort | in vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line hos crl |
| url | http://irep.iium.edu.my/47438/1/5994-16777-1-SM.pdf |
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