Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction
Background Cardiovascular magnetic resonance (CMR) advances in imaging techniques, permits the ability to accurately characterise tissue injury post myocardial infarction. Pre-contrast T1 mapping enables this through measurement of pre-contrast T1 relaxation times. We investigate the relationship b...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier Ltd
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/50701/1/50701_Characterisation%20of%20Myocardial%20Injury.pdf http://irep.iium.edu.my/50701/2/50701_Characterisation%20of%20Myocardial%20Injury_SCOPUS.pdf |
| _version_ | 1825649688717557760 |
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| author | Mohd Shah, Azarisman Shah Carbone, Angelo Shirazi, Mitra Bradley, Julie Teo, Karen S.L Worthley, Matthew I. Worthley, Stephen G. |
| author_facet | Mohd Shah, Azarisman Shah Carbone, Angelo Shirazi, Mitra Bradley, Julie Teo, Karen S.L Worthley, Matthew I. Worthley, Stephen G. |
| author_sort | Mohd Shah, Azarisman Shah |
| collection | IIUM |
| description | Background
Cardiovascular magnetic resonance (CMR) advances in imaging techniques, permits the ability to accurately characterise tissue injury post myocardial infarction. Pre-contrast T1 mapping enables this through measurement of pre-contrast T1 relaxation times. We investigate the relationship between T1 characterisation of myocardial injury with global and regional diastolic function.
Methods Revascularised acute myocardial infarction patients with normal left ventricular (LV) systolic function on TTE were assessed by 1.5T CMR. Acute regional diastolic wall motion abnormalities, global diastolic function measurements, acute segmental damage fraction with LGE and mean segmental pre-contrast T1 values were assessed on matching short axis slices.
Results
Forty-four patients were analysed. Mean LVEF was 62.1 ± 9.4%. No difference between NSTEMI (22/44) and STEMI in mean pre-contrast T1 values of infarcted (1025.0 ± 109.2 vs 1011.0 ± 81.6ms, p = 0.70), adjacent
(948.3 ± 45.3 vs 941.1 ± 46.6 ms, p = 0.70) and remote (888.8 ± 52.8 vs 881.2 ± 54.5 ms, p = 0.66) segments was detected. There was no correlation between pre-contrast T1 of infarcted segments with global diastolic dysfunction
(E/A, r
2 = 0.216, p = 0.06; S/D, r
2 = 0.243, p = 0.053; E/E’, r
2 = 0.240, p = 0.072), but there was significantly positive, moderate correlation with circumferential diastolic strain rate, (r
2 = 0.579, p < 0.01) with excellent agreement and
reproducibility.
Conclusion
Cardiac magnetic resonance evaluation of pre-contrast T1 values revealed no difference between NSTEMI and STEMI patients in terms of tissue characterisation post-myocardial infarction. However, pre-contrast T1 of
infarcted tissue is significantly correlated with regional diastolic circumferential strain rate. |
| first_indexed | 2024-03-05T23:51:14Z |
| format | Article |
| id | oai:generic.eprints.org:50701 |
| institution | International Islamic University Malaysia |
| language | English English |
| last_indexed | 2024-03-05T23:51:14Z |
| publishDate | 2016 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | oai:generic.eprints.org:507012017-04-05T00:49:25Z http://irep.iium.edu.my/50701/ Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction Mohd Shah, Azarisman Shah Carbone, Angelo Shirazi, Mitra Bradley, Julie Teo, Karen S.L Worthley, Matthew I. Worthley, Stephen G. RC Internal medicine Background Cardiovascular magnetic resonance (CMR) advances in imaging techniques, permits the ability to accurately characterise tissue injury post myocardial infarction. Pre-contrast T1 mapping enables this through measurement of pre-contrast T1 relaxation times. We investigate the relationship between T1 characterisation of myocardial injury with global and regional diastolic function. Methods Revascularised acute myocardial infarction patients with normal left ventricular (LV) systolic function on TTE were assessed by 1.5T CMR. Acute regional diastolic wall motion abnormalities, global diastolic function measurements, acute segmental damage fraction with LGE and mean segmental pre-contrast T1 values were assessed on matching short axis slices. Results Forty-four patients were analysed. Mean LVEF was 62.1 ± 9.4%. No difference between NSTEMI (22/44) and STEMI in mean pre-contrast T1 values of infarcted (1025.0 ± 109.2 vs 1011.0 ± 81.6ms, p = 0.70), adjacent (948.3 ± 45.3 vs 941.1 ± 46.6 ms, p = 0.70) and remote (888.8 ± 52.8 vs 881.2 ± 54.5 ms, p = 0.66) segments was detected. There was no correlation between pre-contrast T1 of infarcted segments with global diastolic dysfunction (E/A, r 2 = 0.216, p = 0.06; S/D, r 2 = 0.243, p = 0.053; E/E’, r 2 = 0.240, p = 0.072), but there was significantly positive, moderate correlation with circumferential diastolic strain rate, (r 2 = 0.579, p < 0.01) with excellent agreement and reproducibility. Conclusion Cardiac magnetic resonance evaluation of pre-contrast T1 values revealed no difference between NSTEMI and STEMI patients in terms of tissue characterisation post-myocardial infarction. However, pre-contrast T1 of infarcted tissue is significantly correlated with regional diastolic circumferential strain rate. Elsevier Ltd 2016-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50701/1/50701_Characterisation%20of%20Myocardial%20Injury.pdf application/pdf en http://irep.iium.edu.my/50701/2/50701_Characterisation%20of%20Myocardial%20Injury_SCOPUS.pdf Mohd Shah, Azarisman Shah and Carbone, Angelo and Shirazi, Mitra and Bradley, Julie and Teo, Karen S.L and Worthley, Matthew I. and Worthley, Stephen G. (2016) Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction. Heart Lung and Circulation, 25 (11). pp. 1094-1106. ISSN 1443-9506 E-ISSN 1444-2892 http://www.heartlungcirc.org/article/S1443-9506(16)30070-1/pdf 10.1016/j.hlc.2016.03.011 |
| spellingShingle | RC Internal medicine Mohd Shah, Azarisman Shah Carbone, Angelo Shirazi, Mitra Bradley, Julie Teo, Karen S.L Worthley, Matthew I. Worthley, Stephen G. Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction |
| title | Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction |
| title_full | Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction |
| title_fullStr | Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction |
| title_full_unstemmed | Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction |
| title_short | Characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction |
| title_sort | characterisation of myocardial injury via t1 mapping in early reperfused myocardial infarction and its relationship with global and regional diastolic dysfunction |
| topic | RC Internal medicine |
| url | http://irep.iium.edu.my/50701/1/50701_Characterisation%20of%20Myocardial%20Injury.pdf http://irep.iium.edu.my/50701/2/50701_Characterisation%20of%20Myocardial%20Injury_SCOPUS.pdf |
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