Gastro-retentive drug delivery systems and their in vivo success: A recent update
Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated w...
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Online Access: | http://irep.iium.edu.my/51074/1/Asian_Journal_of_Pharmaceutical_Sciences.pdf |
| _version_ | 1825649738136944640 |
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| author | Mandal, Uttam Kumar Chatterjee, Bappaditya Senjoti, Faria Gias |
| author_facet | Mandal, Uttam Kumar Chatterjee, Bappaditya Senjoti, Faria Gias |
| author_sort | Mandal, Uttam Kumar |
| collection | IIUM |
| description | Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many
challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. Apart from in vitro characterization, successful GRDDS development
demands well designed in vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat. Reported in vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in vitro results. In spite of the many advantages, high subject variations in gastrointestinal physiological condition, effect of food, variable rate of gastric emptying time are the challenges which limit the number of available GRDDS in the market. This review article
highlights the in vivo works of GRDDS carried out in the recent past, including their limitations and challenges need to overcome in the near future. |
| first_indexed | 2024-03-05T23:51:58Z |
| format | Article |
| id | oai:generic.eprints.org:51074 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:51:58Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:generic.eprints.org:510742016-07-19T02:30:35Z http://irep.iium.edu.my/51074/ Gastro-retentive drug delivery systems and their in vivo success: A recent update Mandal, Uttam Kumar Chatterjee, Bappaditya Senjoti, Faria Gias RS Pharmacy and materia medica Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. Apart from in vitro characterization, successful GRDDS development demands well designed in vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat. Reported in vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in vitro results. In spite of the many advantages, high subject variations in gastrointestinal physiological condition, effect of food, variable rate of gastric emptying time are the challenges which limit the number of available GRDDS in the market. This review article highlights the in vivo works of GRDDS carried out in the recent past, including their limitations and challenges need to overcome in the near future. Elsevier 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51074/1/Asian_Journal_of_Pharmaceutical_Sciences.pdf Mandal, Uttam Kumar and Chatterjee, Bappaditya and Senjoti, Faria Gias (2016) Gastro-retentive drug delivery systems and their in vivo success: A recent update. Asian Journal of Pharmaceutical Sciences. pp. 1-25. ISSN 1818-0876 (In Press) http://www.sciencedirect.com/science/article/pii/S1818087616300320 10.1016/j.ajps.2016.04.007 |
| spellingShingle | RS Pharmacy and materia medica Mandal, Uttam Kumar Chatterjee, Bappaditya Senjoti, Faria Gias Gastro-retentive drug delivery systems and their in vivo success: A recent update |
| title | Gastro-retentive drug delivery systems and their in vivo success: A recent update |
| title_full | Gastro-retentive drug delivery systems and their in vivo success: A recent update |
| title_fullStr | Gastro-retentive drug delivery systems and their in vivo success: A recent update |
| title_full_unstemmed | Gastro-retentive drug delivery systems and their in vivo success: A recent update |
| title_short | Gastro-retentive drug delivery systems and their in vivo success: A recent update |
| title_sort | gastro retentive drug delivery systems and their in vivo success a recent update |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/51074/1/Asian_Journal_of_Pharmaceutical_Sciences.pdf |
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