Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration
Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteri...
| Main Authors: | , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2011
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| Online Access: | http://irep.iium.edu.my/5167/1/poster_101_iriie_2011.pdf |
| _version_ | 1796875223524442112 |
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| author | Abdul Majeed, Saif Saad Saxena, Anil Kumar |
| author_facet | Abdul Majeed, Saif Saad Saxena, Anil Kumar |
| author_sort | Abdul Majeed, Saif Saad |
| collection | IIUM |
| description | Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders, the present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occurs in response to increased oxidative stress following ischemic insult. |
| first_indexed | 2024-03-05T22:35:40Z |
| format | Proceeding Paper |
| id | oai:generic.eprints.org:5167 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:35:40Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oai:generic.eprints.org:51672011-11-21T16:19:38Z http://irep.iium.edu.my/5167/ Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration Abdul Majeed, Saif Saad Saxena, Anil Kumar R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders, the present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occurs in response to increased oxidative stress following ischemic insult. 2011-02 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/5167/1/poster_101_iriie_2011.pdf Abdul Majeed, Saif Saad and Saxena, Anil Kumar (2011) Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration. In: Enhancing Quality Research and Innovation for Societal Development, 9-10 February 2011, IIUM, Gombak. http://iium.edu.my |
| spellingShingle | R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease Abdul Majeed, Saif Saad Saxena, Anil Kumar Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration |
| title | Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration |
| title_full | Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration |
| title_fullStr | Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration |
| title_full_unstemmed | Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration |
| title_short | Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration |
| title_sort | assessment of reactive oxygen species ros status in chronic cerebral hypoperfusion induced neurodegeneration |
| topic | R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease |
| url | http://irep.iium.edu.my/5167/1/poster_101_iriie_2011.pdf |
| work_keys_str_mv | AT abdulmajeedsaifsaad assessmentofreactiveoxygenspeciesrosstatusinchroniccerebralhypoperfusioninducedneurodegeneration AT saxenaanilkumar assessmentofreactiveoxygenspeciesrosstatusinchroniccerebralhypoperfusioninducedneurodegeneration |