CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia
Introduction: Genetic polymorphisms of CYP2C9 among different populations in different geographical regions could be dif ferent . CYP2C9 has been reported to be the enzyme responsible for the metabolism of many drugs, including warfarin and other drugs with a narrow therapeutic index. Realisin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Singapore Medical Association
2009
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/5194/1/CYP2C9_Poly_in_SMJ_2009.pdf |
| _version_ | 1796875226326237184 |
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| author | Ngow, Harris Abdullah Wan Khairina, Wan Mohd Nowalid Teh , Lay Kek Lee, Wee Leng Harun, Roslan Ismail, Rusli Salleh, Mohd Zaki |
| author_facet | Ngow, Harris Abdullah Wan Khairina, Wan Mohd Nowalid Teh , Lay Kek Lee, Wee Leng Harun, Roslan Ismail, Rusli Salleh, Mohd Zaki |
| author_sort | Ngow, Harris Abdullah |
| collection | IIUM |
| description | Introduction: Genetic polymorphisms of
CYP2C9 among different populations in different
geographical regions could be dif ferent .
CYP2C9 has been reported to be the enzyme
responsible for the metabolism of many drugs,
including warfarin and other drugs with a narrow
therapeutic index. Realising the importance of
inter-individual differences in the genetic profile
in determining the outcome of a drug therapy,
this study was conducted to explore the types
and frequencies of CYP2C9 alleles in healthy
and warfarin-treated Malays and Chinese, the
two major ethnic groups in Malaysia. We aimed
to evaluate the prevalence of the types and
frequencies of common CYP2C9 alleles (*1, *2, *3
and *4) among the healthy unrelated individuals
and diseased patients prescribed with warfarin. |
| first_indexed | 2024-03-05T22:35:42Z |
| format | Article |
| id | oai:generic.eprints.org:5194 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:35:42Z |
| publishDate | 2009 |
| publisher | Singapore Medical Association |
| record_format | dspace |
| spelling | oai:generic.eprints.org:51942011-11-18T02:10:32Z http://irep.iium.edu.my/5194/ CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia Ngow, Harris Abdullah Wan Khairina, Wan Mohd Nowalid Teh , Lay Kek Lee, Wee Leng Harun, Roslan Ismail, Rusli Salleh, Mohd Zaki RC Internal medicine RM Therapeutics. Pharmacology Introduction: Genetic polymorphisms of CYP2C9 among different populations in different geographical regions could be dif ferent . CYP2C9 has been reported to be the enzyme responsible for the metabolism of many drugs, including warfarin and other drugs with a narrow therapeutic index. Realising the importance of inter-individual differences in the genetic profile in determining the outcome of a drug therapy, this study was conducted to explore the types and frequencies of CYP2C9 alleles in healthy and warfarin-treated Malays and Chinese, the two major ethnic groups in Malaysia. We aimed to evaluate the prevalence of the types and frequencies of common CYP2C9 alleles (*1, *2, *3 and *4) among the healthy unrelated individuals and diseased patients prescribed with warfarin. Singapore Medical Association 2009 Article PeerReviewed application/pdf en http://irep.iium.edu.my/5194/1/CYP2C9_Poly_in_SMJ_2009.pdf Ngow, Harris Abdullah and Wan Khairina, Wan Mohd Nowalid and Teh , Lay Kek and Lee, Wee Leng and Harun, Roslan and Ismail, Rusli and Salleh, Mohd Zaki (2009) CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia. Singapore Medical Journal, 50 (5). pp. 490-493. ISSN 0037-5675 http://smj.sma.org.sg/5005/5005a6.pdf |
| spellingShingle | RC Internal medicine RM Therapeutics. Pharmacology Ngow, Harris Abdullah Wan Khairina, Wan Mohd Nowalid Teh , Lay Kek Lee, Wee Leng Harun, Roslan Ismail, Rusli Salleh, Mohd Zaki CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
| title | CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
| title_full | CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
| title_fullStr | CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
| title_full_unstemmed | CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
| title_short | CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
| title_sort | cyp2c9 polymorphism prevalence in healthy and warfarin treated malay and chinese in malaysia |
| topic | RC Internal medicine RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/5194/1/CYP2C9_Poly_in_SMJ_2009.pdf |
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