Beyond classical meta-analysis: can inadequately reported studies be included?
Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to inclu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier Science Limited
2004
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/5556/1/DDT_beyond_classical_MA.pdf |
| _version_ | 1796875273363259392 |
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| author | Roberson, Chris Nik Idris, Nik Ruzni Boyle, Peter |
| author_facet | Roberson, Chris Nik Idris, Nik Ruzni Boyle, Peter |
| author_sort | Roberson, Chris |
| collection | IIUM |
| description | Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the use of non-randomized single-arm studies and studies against comparator treatments has little influence on the estimation of the treatment effect in comparison with placebo, an effect that is based on the randomized placebo-controlled studies. The inclusion of other studies serves to increase the precision of the effect of the treatment compared with baseline. Although multiple imputation techniques enable a larger number of studies to be included, which will typically increase the precision of the estimated effect, a careful sensitivity analysis is also required |
| first_indexed | 2024-03-05T22:36:23Z |
| format | Article |
| id | oai:generic.eprints.org:5556 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:36:23Z |
| publishDate | 2004 |
| publisher | Elsevier Science Limited |
| record_format | dspace |
| spelling | oai:generic.eprints.org:55562011-11-21T23:14:56Z http://irep.iium.edu.my/5556/ Beyond classical meta-analysis: can inadequately reported studies be included? Roberson, Chris Nik Idris, Nik Ruzni Boyle, Peter HA Statistics Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the use of non-randomized single-arm studies and studies against comparator treatments has little influence on the estimation of the treatment effect in comparison with placebo, an effect that is based on the randomized placebo-controlled studies. The inclusion of other studies serves to increase the precision of the effect of the treatment compared with baseline. Although multiple imputation techniques enable a larger number of studies to be included, which will typically increase the precision of the estimated effect, a careful sensitivity analysis is also required Elsevier Science Limited 2004-11-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/5556/1/DDT_beyond_classical_MA.pdf Roberson, Chris and Nik Idris, Nik Ruzni and Boyle, Peter (2004) Beyond classical meta-analysis: can inadequately reported studies be included? Drug Discovery Today, 9 (21). pp. 924-931. ISSN 1359-6446 http://www.sciencedirect.com/science/article/pii/S135964460403274X doi:10.1016/S1359-6446(04)03274-X |
| spellingShingle | HA Statistics Roberson, Chris Nik Idris, Nik Ruzni Boyle, Peter Beyond classical meta-analysis: can inadequately reported studies be included? |
| title | Beyond classical meta-analysis: can inadequately reported studies be included? |
| title_full | Beyond classical meta-analysis: can inadequately reported studies be included? |
| title_fullStr | Beyond classical meta-analysis: can inadequately reported studies be included? |
| title_full_unstemmed | Beyond classical meta-analysis: can inadequately reported studies be included? |
| title_short | Beyond classical meta-analysis: can inadequately reported studies be included? |
| title_sort | beyond classical meta analysis can inadequately reported studies be included |
| topic | HA Statistics |
| url | http://irep.iium.edu.my/5556/1/DDT_beyond_classical_MA.pdf |
| work_keys_str_mv | AT robersonchris beyondclassicalmetaanalysiscaninadequatelyreportedstudiesbeincluded AT nikidrisnikruzni beyondclassicalmetaanalysiscaninadequatelyreportedstudiesbeincluded AT boylepeter beyondclassicalmetaanalysiscaninadequatelyreportedstudiesbeincluded |