Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis
A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2009
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/7964/1/irwandi_2009._JLCRT.pdf |
| _version_ | 1796875571466076160 |
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| author | Khatib, Alfi Yuliana, Nancy Dewi Jinap, Selamat Sarker, Md. Zaidul Islam Jaswir, Irwandi Wilson, Erica G. Shin-Kyo, Chung Verpoorte, Robert |
| author_facet | Khatib, Alfi Yuliana, Nancy Dewi Jinap, Selamat Sarker, Md. Zaidul Islam Jaswir, Irwandi Wilson, Erica G. Shin-Kyo, Chung Verpoorte, Robert |
| author_sort | Khatib, Alfi |
| collection | IIUM |
| description | A novel approach to identify compounds possessing adenosine
A1 receptor binding activity in the leaves of O. stamineus was developed.
O. stamineus extract is one of the components of a functional beverage used in
Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor
binding, which is related to the diuretic action in the treatment of kidney stones
was tested. A combination of thin layer chromatography of different extracts
prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol
and water), and multivariate data analysis based on orthogonal partial least
squares proved to be a promising approach to determine these active compounds.
Several methoxyflavonoids, fatty acids or terpenoids were estimated to be relatedto this activity. The results of this study support the traditional use in Indonesia
of O. stamineus as a functional drink to treat kidney stones |
| first_indexed | 2024-03-05T22:40:38Z |
| format | Article |
| id | oai:generic.eprints.org:7964 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:40:38Z |
| publishDate | 2009 |
| publisher | Taylor & Francis Group |
| record_format | dspace |
| spelling | oai:generic.eprints.org:79642013-12-16T05:03:22Z http://irep.iium.edu.my/7964/ Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis Khatib, Alfi Yuliana, Nancy Dewi Jinap, Selamat Sarker, Md. Zaidul Islam Jaswir, Irwandi Wilson, Erica G. Shin-Kyo, Chung Verpoorte, Robert QD Chemistry A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxyflavonoids, fatty acids or terpenoids were estimated to be relatedto this activity. The results of this study support the traditional use in Indonesia of O. stamineus as a functional drink to treat kidney stones Taylor & Francis Group 2009 Article PeerReviewed application/pdf en http://irep.iium.edu.my/7964/1/irwandi_2009._JLCRT.pdf Khatib, Alfi and Yuliana, Nancy Dewi and Jinap, Selamat and Sarker, Md. Zaidul Islam and Jaswir, Irwandi and Wilson, Erica G. and Shin-Kyo, Chung and Verpoorte, Robert (2009) Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. Journal of Liquid Chromatography & Related Technologies, 32. pp. 2906-2916. ISSN 1520-572X (O), 1082-6076 (P) http://www.tandf.co.uk/journals/titles/10826076.asp DOI: 10.1080/10826070903297459 |
| spellingShingle | QD Chemistry Khatib, Alfi Yuliana, Nancy Dewi Jinap, Selamat Sarker, Md. Zaidul Islam Jaswir, Irwandi Wilson, Erica G. Shin-Kyo, Chung Verpoorte, Robert Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis |
| title | Identification of possible compounds possessing
adenosine A1 receptor binding activity in the
leaves of orthosiphon stamineus using TLC
and multivariate data analysis |
| title_full | Identification of possible compounds possessing
adenosine A1 receptor binding activity in the
leaves of orthosiphon stamineus using TLC
and multivariate data analysis |
| title_fullStr | Identification of possible compounds possessing
adenosine A1 receptor binding activity in the
leaves of orthosiphon stamineus using TLC
and multivariate data analysis |
| title_full_unstemmed | Identification of possible compounds possessing
adenosine A1 receptor binding activity in the
leaves of orthosiphon stamineus using TLC
and multivariate data analysis |
| title_short | Identification of possible compounds possessing
adenosine A1 receptor binding activity in the
leaves of orthosiphon stamineus using TLC
and multivariate data analysis |
| title_sort | identification of possible compounds possessing adenosine a1 receptor binding activity in the leaves of orthosiphon stamineus using tlc and multivariate data analysis |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/7964/1/irwandi_2009._JLCRT.pdf |
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