Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta
Background: In 2007 Oncology Ginecology Indonesia Society found that from all of ginecology cancer 32% are ovarian carcinoma. About 91% of ovarian carcinoma are of epithelial cell and most of them came on late stadium, stadium III – IV (75%). Apoptosis is a program of cell death, if unrepaired DNA n...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2009
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| _version_ | 1826042233688686592 |
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| author | ADIYANTI, Vika Puspa |
| author_facet | ADIYANTI, Vika Puspa |
| author_sort | ADIYANTI, Vika Puspa |
| collection | UGM |
| description | Background: In 2007 Oncology Ginecology Indonesia Society found that from all of ginecology cancer 32% are ovarian carcinoma. About 91% of ovarian carcinoma are of epithelial cell and most of them came on late stadium, stadium III – IV (75%). Apoptosis is a program of cell death, if unrepaired DNA not eliminate, than it will distrubing the cell growth. In this proses p53, a tumor supressor gene and bcl-2, an apoptosis gene involved. If there is unstable of these protein than apoptosis will occur and can cause an abnormal cell growth. Objective: to know the correlation between stadium of ovarian carcinoma Study design: Cross sectional method Material and method: This study was performed at oncology departement Sardjito Hospital,Yogyakarta. The subjects are 34 patients who diagnosed ovarian carcinoma and taking care in oncology departement Sradjito Hospital. P53,bcl-2 ekxpresion and apoptosis indeks are evaluate from the ovarian tissue. Result: From 34 patient we found that 2,9% are in first stadium and 41,2% are third stadium of ovarian carcinoma. Form the statistical analitics Pearson, we found that there is significant correlation between bcl-2 and ovarian carcinoma and apoptosis. Beside that correlation between p53 and ovarian carcinoma stadium and apoptosis also significant with p < 0,01 Conclusion: There is significant correlation between ovarian carcinoma stadium with p53 , bcl-2 expresion and apoptosis indeks. |
| first_indexed | 2024-03-13T21:44:27Z |
| format | Thesis |
| id | oai:generic.eprints.org:82398 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T21:44:27Z |
| publishDate | 2009 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:823982016-04-21T02:31:54Z https://repository.ugm.ac.id/82398/ Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta ADIYANTI, Vika Puspa Reproduction Obstetrics and Gynaecology Background: In 2007 Oncology Ginecology Indonesia Society found that from all of ginecology cancer 32% are ovarian carcinoma. About 91% of ovarian carcinoma are of epithelial cell and most of them came on late stadium, stadium III – IV (75%). Apoptosis is a program of cell death, if unrepaired DNA not eliminate, than it will distrubing the cell growth. In this proses p53, a tumor supressor gene and bcl-2, an apoptosis gene involved. If there is unstable of these protein than apoptosis will occur and can cause an abnormal cell growth. Objective: to know the correlation between stadium of ovarian carcinoma Study design: Cross sectional method Material and method: This study was performed at oncology departement Sardjito Hospital,Yogyakarta. The subjects are 34 patients who diagnosed ovarian carcinoma and taking care in oncology departement Sradjito Hospital. P53,bcl-2 ekxpresion and apoptosis indeks are evaluate from the ovarian tissue. Result: From 34 patient we found that 2,9% are in first stadium and 41,2% are third stadium of ovarian carcinoma. Form the statistical analitics Pearson, we found that there is significant correlation between bcl-2 and ovarian carcinoma and apoptosis. Beside that correlation between p53 and ovarian carcinoma stadium and apoptosis also significant with p < 0,01 Conclusion: There is significant correlation between ovarian carcinoma stadium with p53 , bcl-2 expresion and apoptosis indeks. [Yogyakarta] : Universitas Gadjah Mada 2009 Thesis NonPeerReviewed ADIYANTI, Vika Puspa (2009) Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta. Masters thesis, Universitas Gadjah Mada. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=43262 |
| spellingShingle | Reproduction Obstetrics and Gynaecology ADIYANTI, Vika Puspa Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta |
| title | Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta |
| title_full | Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta |
| title_fullStr | Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta |
| title_full_unstemmed | Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta |
| title_short | Hubungan antara ekspresi P53 dan BeL-2 serta indeks apoptosis dengan stadium karsinoma ovarium di RS. Dr. Sardjito Yogyakarta |
| title_sort | hubungan antara ekspresi p53 dan bel 2 serta indeks apoptosis dengan stadium karsinoma ovarium di rs dr sardjito yogyakarta |
| topic | Reproduction Obstetrics and Gynaecology |
| work_keys_str_mv | AT adiyantivikapuspa hubunganantaraekspresip53danbel2sertaindeksapoptosisdenganstadiumkarsinomaovariumdirsdrsardjitoyogyakarta |