Comparison of disintegrant-addition methods on the compounding of orodispersible tablets
Orodispersible tablets disintegrate rapidly (within 3 minutes) in the oral cavity and release the medicament before swallowing. The mode of disintegrant addition might affect the properties of orodispersible tablets. The objective of this study was to formulate and evaluate orodispersible tablets...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/82584/7/82584_Comparison%20of%20Disintegrant%20addition%20Methods%20on%20the%20Compounding%20of%20Orodispersible.pdf http://irep.iium.edu.my/82584/13/82584_Comparison%20of%20disintegrant-addition%20methods.pdf |
| Summary: | Orodispersible tablets disintegrate rapidly (within 3 minutes)
in the oral cavity and release the medicament before swallowing. The mode of disintegrant addition might affect the properties of orodispersible tablets. The objective of this
study was to formulate and evaluate orodispersible tablets
by studying different modes of disintegration addition with
varying concentrations of disintegrants. The wet granulation
method was used to produce the orodispersible tablets. Two
methods of disintegration addition were compared (i.e.,
intragranular, extragranular). Three disintegrants (i.e., cornstarch, sodium starch glycolate, crospovidone) were used at three levels (5%, 10%, and 15%) in the study. The formulations were tested for the powder flowability (angle of
repose) and characterized physically (hardness, weight,
thickness, friability, disintegration time). The mangosteen
pericarp extract was used as a model active pharmaceutical
ingredient to be incorporated into the optimum formulation.
It was observed that the extragranular method produced
granules with better flowability compared to that of the
intragranular method. Crospovidone was found as the most
efficient disintegrant among the three. The optimum formulation selected was one with the highest concentration of crospovidone (15%), which showed the fastest disintegration time. The mode of disintegrant addition into the orodispersible tablets formulation was found to show a marked difference in the disintegration, as well as other physical characteristics of the orodispersible tablets where the extragranular mode of addition showed better property, which caused the orodispersible tablets to disintegrate the fastest. |
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