Comparison of disintegrant-addition methods on the compounding of orodispersible tablets
Orodispersible tablets disintegrate rapidly (within 3 minutes) in the oral cavity and release the medicament before swallowing. The mode of disintegrant addition might affect the properties of orodispersible tablets. The objective of this study was to formulate and evaluate orodispersible tablets...
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| Format: | Article |
| Language: | English English |
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2020
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| Online Access: | http://irep.iium.edu.my/82584/7/82584_Comparison%20of%20Disintegrant%20addition%20Methods%20on%20the%20Compounding%20of%20Orodispersible.pdf http://irep.iium.edu.my/82584/13/82584_Comparison%20of%20disintegrant-addition%20methods.pdf |
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| author | Mahesparan, Vishnu Abd Razak,, Fashli Syafiq Long, Chiau Ming Helal Uddin, A.B.M. Sarker, Md. Zaidul Islam Liew, Kai Bin |
| author_facet | Mahesparan, Vishnu Abd Razak,, Fashli Syafiq Long, Chiau Ming Helal Uddin, A.B.M. Sarker, Md. Zaidul Islam Liew, Kai Bin |
| author_sort | Mahesparan, Vishnu |
| collection | IIUM |
| description | Orodispersible tablets disintegrate rapidly (within 3 minutes)
in the oral cavity and release the medicament before swallowing. The mode of disintegrant addition might affect the properties of orodispersible tablets. The objective of this
study was to formulate and evaluate orodispersible tablets
by studying different modes of disintegration addition with
varying concentrations of disintegrants. The wet granulation
method was used to produce the orodispersible tablets. Two
methods of disintegration addition were compared (i.e.,
intragranular, extragranular). Three disintegrants (i.e., cornstarch, sodium starch glycolate, crospovidone) were used at three levels (5%, 10%, and 15%) in the study. The formulations were tested for the powder flowability (angle of
repose) and characterized physically (hardness, weight,
thickness, friability, disintegration time). The mangosteen
pericarp extract was used as a model active pharmaceutical
ingredient to be incorporated into the optimum formulation.
It was observed that the extragranular method produced
granules with better flowability compared to that of the
intragranular method. Crospovidone was found as the most
efficient disintegrant among the three. The optimum formulation selected was one with the highest concentration of crospovidone (15%), which showed the fastest disintegration time. The mode of disintegrant addition into the orodispersible tablets formulation was found to show a marked difference in the disintegration, as well as other physical characteristics of the orodispersible tablets where the extragranular mode of addition showed better property, which caused the orodispersible tablets to disintegrate the fastest. |
| first_indexed | 2024-03-06T00:50:01Z |
| format | Article |
| id | oai:generic.eprints.org:82584 |
| institution | International Islamic University Malaysia |
| language | English English |
| last_indexed | 2024-03-06T00:50:01Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | oai:generic.eprints.org:825842022-07-07T07:38:36Z http://irep.iium.edu.my/82584/ Comparison of disintegrant-addition methods on the compounding of orodispersible tablets Mahesparan, Vishnu Abd Razak,, Fashli Syafiq Long, Chiau Ming Helal Uddin, A.B.M. Sarker, Md. Zaidul Islam Liew, Kai Bin RM Therapeutics. Pharmacology RS192 Materia Medica-Pharmaceutical Technology Orodispersible tablets disintegrate rapidly (within 3 minutes) in the oral cavity and release the medicament before swallowing. The mode of disintegrant addition might affect the properties of orodispersible tablets. The objective of this study was to formulate and evaluate orodispersible tablets by studying different modes of disintegration addition with varying concentrations of disintegrants. The wet granulation method was used to produce the orodispersible tablets. Two methods of disintegration addition were compared (i.e., intragranular, extragranular). Three disintegrants (i.e., cornstarch, sodium starch glycolate, crospovidone) were used at three levels (5%, 10%, and 15%) in the study. The formulations were tested for the powder flowability (angle of repose) and characterized physically (hardness, weight, thickness, friability, disintegration time). The mangosteen pericarp extract was used as a model active pharmaceutical ingredient to be incorporated into the optimum formulation. It was observed that the extragranular method produced granules with better flowability compared to that of the intragranular method. Crospovidone was found as the most efficient disintegrant among the three. The optimum formulation selected was one with the highest concentration of crospovidone (15%), which showed the fastest disintegration time. The mode of disintegrant addition into the orodispersible tablets formulation was found to show a marked difference in the disintegration, as well as other physical characteristics of the orodispersible tablets where the extragranular mode of addition showed better property, which caused the orodispersible tablets to disintegrate the fastest. 2020-03-31 Article PeerReviewed application/pdf en http://irep.iium.edu.my/82584/7/82584_Comparison%20of%20Disintegrant%20addition%20Methods%20on%20the%20Compounding%20of%20Orodispersible.pdf application/pdf en http://irep.iium.edu.my/82584/13/82584_Comparison%20of%20disintegrant-addition%20methods.pdf Mahesparan, Vishnu and Abd Razak,, Fashli Syafiq and Long, Chiau Ming and Helal Uddin, A.B.M. and Sarker, Md. Zaidul Islam and Liew, Kai Bin (2020) Comparison of disintegrant-addition methods on the compounding of orodispersible tablets. International Journal of Pharmaceutical Compounding, 24 (2). pp. 148-155. ISSN 1092-4221 https://ijpc.com/Abstracts/Abstract.cfm?ABS=4777 |
| spellingShingle | RM Therapeutics. Pharmacology RS192 Materia Medica-Pharmaceutical Technology Mahesparan, Vishnu Abd Razak,, Fashli Syafiq Long, Chiau Ming Helal Uddin, A.B.M. Sarker, Md. Zaidul Islam Liew, Kai Bin Comparison of disintegrant-addition methods on the compounding of orodispersible tablets |
| title | Comparison of disintegrant-addition methods on the compounding of orodispersible tablets |
| title_full | Comparison of disintegrant-addition methods on the compounding of orodispersible tablets |
| title_fullStr | Comparison of disintegrant-addition methods on the compounding of orodispersible tablets |
| title_full_unstemmed | Comparison of disintegrant-addition methods on the compounding of orodispersible tablets |
| title_short | Comparison of disintegrant-addition methods on the compounding of orodispersible tablets |
| title_sort | comparison of disintegrant addition methods on the compounding of orodispersible tablets |
| topic | RM Therapeutics. Pharmacology RS192 Materia Medica-Pharmaceutical Technology |
| url | http://irep.iium.edu.my/82584/7/82584_Comparison%20of%20Disintegrant%20addition%20Methods%20on%20the%20Compounding%20of%20Orodispersible.pdf http://irep.iium.edu.my/82584/13/82584_Comparison%20of%20disintegrant-addition%20methods.pdf |
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