| Summary: | Arterial hypertension affects heart tissue composition which leads to structural remodeling of the myocardium. The imbalance between synthesis and degradation of type I collagen leading to myocardial fibrosis in a form of type I collagen fiber accumulation in the interstitial and perivascular myocardium. Collagen fiber accumulation reduces relaxation stage, diastolic suction, myocardial stiffness and diastolic disfunction which affects systolic disfunction leading to heart failure. Concentration of carboxy-terminal propeptide of procollagen type I (PIP) in peripheral blood is a synthesis index of type I collagen in HHD. Thus, the measurement of PIP is useful to monitor myocardial fibrosis stage in heart failure and to determine the therapeutic strategy that aims not only to reduce arterial pressure and left ventricular mass but also to prevent myocardial remodeling.
This research aimed to determine difference PIP level in patients heart failure stage A, B, and C caused heart failure which is caused by hypertension. This research was a cross sectional research designed for cardiology policlinic’s outpatients at Dr Sardjito General Hospital Yogyakarta from August 2009 until the calculated sample number is fulfilled. One-way ANOVA was used to analyze the differences between the three groups of heart failure stages which was followed by Student-Newman-Keuls test after being tested for the normality using Shapiro-Wilks normality test, if the result didn’t show a normal value, a non-parametric test would be undergone using Kruskal-Wallis test followed by Mann-Whitney U test. The differences considered as significant if p < 0.05 with confidence interval of 95%.
Research result showed the characteristics of research subjects based on age, sex, BMI, systolic and diastolic blood pressure, heart rate, hypertension stage, duration of hypertension, hypertension medications, ejection fraction, interventricular septum thickness, posterior wall thickness end diastolic, left ventricle internal diameter at end-diastolic, left ventricle mass index and left ventricular hypertrophy. Moreover, this research brought some advantages upon therapeutic strategy for patients with heart failure caused by hypertension.
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