KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK
A number of laboratory indexes has been proposed as potential marker for prognostic factors of stroke, one of them is D-dimer value. D-dimer may be useful to determine the extent of fibrin development as well as to assess wether there is a change in the process.The objective of this study is to asse...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2011
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| author | , dr. Lucyana Ani Debora Tampubolan , dr. Setyawati, Sp.PK-K. |
| author_facet | , dr. Lucyana Ani Debora Tampubolan , dr. Setyawati, Sp.PK-K. |
| author_sort | , dr. Lucyana Ani Debora Tampubolan |
| collection | UGM |
| description | A number of laboratory indexes has been proposed as potential marker for prognostic
factors of stroke, one of them is D-dimer value. D-dimer may be useful to determine the
extent of fibrin development as well as to assess wether there is a change in the process.The
objective of this study is to assess the role of high D-dimer value for the prognosis of
infarction stroke.
This is a prognostic study with prospective cohort design of patients treated in Stroke
Unit. Quantification of D-dimer value was measured with enzyme linked fluorescent assay
(ELFA), meanwhile infarction stroke outcome was determined by the difference of SSGM
score between admission and day 5 post-stroke. Relative Risk (RR) of higher D-dimer values
compared with normal D-dimer value in infarction stroke patients was calculated, with p
value of < 0.05 is considered as significant.
Total 62 patients with infarction stroke was enrolled in the study, 40 of them had Ddimer
value > 500 ng/mL. 28 patients had poor clinical outcome. Univariate analysis results
indicated that higher D-dimer value (RR = 2,530, p = 0,015), admission SSGM score
(RR = 1,957, p = 0,019)), diabetes mellitus history (RR= 1,855, p = 0,044) and dyslipidemia
(RR= 2,455, p = 0,026). After multivariate analysis, D-dimer (RR = 5,892, p = 0,008) and
dyslipidemia (RR = 4,351, p = 0,041) were independent prognostic factors for clinical
outcome in infarction stroke patients. Higher D-dimer level is independently associated with
clinical outcome of acute infarction stroke patients. Patiens with high D-dimer value had RR
of 5,892 (95% CI 1,585-20,836) for worse clinical outcome with considering the limitation.
Key word : D-dimer, prognostic, infarction stroke |
| first_indexed | 2024-03-13T22:03:48Z |
| format | Thesis |
| id | oai:generic.eprints.org:88391 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:03:48Z |
| publishDate | 2011 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:883912014-08-20T02:54:36Z https://repository.ugm.ac.id/88391/ KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK , dr. Lucyana Ani Debora Tampubolan , dr. Setyawati, Sp.PK-K. ETD A number of laboratory indexes has been proposed as potential marker for prognostic factors of stroke, one of them is D-dimer value. D-dimer may be useful to determine the extent of fibrin development as well as to assess wether there is a change in the process.The objective of this study is to assess the role of high D-dimer value for the prognosis of infarction stroke. This is a prognostic study with prospective cohort design of patients treated in Stroke Unit. Quantification of D-dimer value was measured with enzyme linked fluorescent assay (ELFA), meanwhile infarction stroke outcome was determined by the difference of SSGM score between admission and day 5 post-stroke. Relative Risk (RR) of higher D-dimer values compared with normal D-dimer value in infarction stroke patients was calculated, with p value of < 0.05 is considered as significant. Total 62 patients with infarction stroke was enrolled in the study, 40 of them had Ddimer value > 500 ng/mL. 28 patients had poor clinical outcome. Univariate analysis results indicated that higher D-dimer value (RR = 2,530, p = 0,015), admission SSGM score (RR = 1,957, p = 0,019)), diabetes mellitus history (RR= 1,855, p = 0,044) and dyslipidemia (RR= 2,455, p = 0,026). After multivariate analysis, D-dimer (RR = 5,892, p = 0,008) and dyslipidemia (RR = 4,351, p = 0,041) were independent prognostic factors for clinical outcome in infarction stroke patients. Higher D-dimer level is independently associated with clinical outcome of acute infarction stroke patients. Patiens with high D-dimer value had RR of 5,892 (95% CI 1,585-20,836) for worse clinical outcome with considering the limitation. Key word : D-dimer, prognostic, infarction stroke [Yogyakarta] : Universitas Gadjah Mada 2011 Thesis NonPeerReviewed , dr. Lucyana Ani Debora Tampubolan and , dr. Setyawati, Sp.PK-K. (2011) KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=50189 |
| spellingShingle | ETD , dr. Lucyana Ani Debora Tampubolan , dr. Setyawati, Sp.PK-K. KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK |
| title | KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK |
| title_full | KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK |
| title_fullStr | KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK |
| title_full_unstemmed | KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK |
| title_short | KADAR D-DIMER TINGGI SEBAGAI FAKTOR PROGNOSIS LUARAN KLINIS PADA STROKE INFARK |
| title_sort | kadar d dimer tinggi sebagai faktor prognosis luaran klinis pada stroke infark |
| topic | ETD |
| work_keys_str_mv | AT drlucyanaanideboratampubolan kadarddimertinggisebagaifaktorprognosisluaranklinispadastrokeinfark AT drsetyawatisppkk kadarddimertinggisebagaifaktorprognosisluaranklinispadastrokeinfark |