POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN (Tinjauan Pustaka dan Laporan Penelitian)
Background: Hypertension is considered as a multifactorial trait resulting from a combination of environmental and genetic factors. Genetic mutation is rare, when genetic mutation more than 1% population called as polymorphism. There are many genes polymorphism associated with hypertension. Polymorp...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2011
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| author | , SUTARSO KAMAJAYA , Prof. Dr. dr. Moch. Sja'bani, M.Med.Sc., SpPD-KGH |
| author_facet | , SUTARSO KAMAJAYA , Prof. Dr. dr. Moch. Sja'bani, M.Med.Sc., SpPD-KGH |
| author_sort | , SUTARSO KAMAJAYA |
| collection | UGM |
| description | Background: Hypertension is considered as a multifactorial trait resulting from a combination
of environmental and genetic factors. Genetic mutation is rare, when genetic mutation more than
1% population called as polymorphism. There are many genes polymorphism associated with
hypertension. Polymorphism of the genes coded in the component of Renin-angiotensinaldosteron
system (RAAS) are potential influence essential hypertension. The popular
polymorphism was a insertion/deletion (I/D) in ACE gene. Recent studies showed that DD
genotype and D allele have been associated with higher prevalence of hypertension. There is no
data reported so far about the possible effect of I/D polymorphism of the ACE gene and
hypertension in Javanese population based on community. There is a wide variation in ACE gene
polymorphism among the ethnics.
Objective: To investigate ACE gene polymorphism in hypertensive subjects in Javanese
population.
Methode: A case control study by matching of sex and age, was conducted in August 2008-July
2009, based on community at district of Sleman-Yogyakarta. The covered subjects were 12073
over 17 years, after selected by aged of 30-59 years old, we get 7695 people and grouped in
normotension, pre-hypertension and hypertension. Stratified randomize was done to select 51 for
hypertension and 51 normotension involving this study. Genotypes based on the polymorphisms
(II/ID/DD) using a polymerase chain reaction (PCR) methode, at Biochemistry Laboratory
Faculty of Medicine Gadjah Mada University Yogyakarta.
Results: The genotype frequencies in hypertensive group versus normal were II 23(45.0%) vs
37(72.5%), ID 25(49.0%) vs 13(25.5%) and DD 3(6.0%) vs 1(2.0%) p=0.043. The allele
frequencies were I allele 35(68.5%) vs 43(84.5%), D allele 16(31.5%) vs 8(15.5%), p=0.038.
Logistic regression analysis showed that D allele as a risk factor for hypertension.
Conclusion: Frequencies of ID and DD genotypes and D allele ACE gene in hypertensive
subject were higher than normotensive subjects. The D allele of the ACE gene was a
predisposing factor in hypertension. |
| first_indexed | 2024-03-13T22:08:05Z |
| format | Thesis |
| id | oai:generic.eprints.org:89693 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:08:05Z |
| publishDate | 2011 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:896932014-08-20T02:53:47Z https://repository.ugm.ac.id/89693/ POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN (Tinjauan Pustaka dan Laporan Penelitian) , SUTARSO KAMAJAYA , Prof. Dr. dr. Moch. Sja'bani, M.Med.Sc., SpPD-KGH ETD Background: Hypertension is considered as a multifactorial trait resulting from a combination of environmental and genetic factors. Genetic mutation is rare, when genetic mutation more than 1% population called as polymorphism. There are many genes polymorphism associated with hypertension. Polymorphism of the genes coded in the component of Renin-angiotensinaldosteron system (RAAS) are potential influence essential hypertension. The popular polymorphism was a insertion/deletion (I/D) in ACE gene. Recent studies showed that DD genotype and D allele have been associated with higher prevalence of hypertension. There is no data reported so far about the possible effect of I/D polymorphism of the ACE gene and hypertension in Javanese population based on community. There is a wide variation in ACE gene polymorphism among the ethnics. Objective: To investigate ACE gene polymorphism in hypertensive subjects in Javanese population. Methode: A case control study by matching of sex and age, was conducted in August 2008-July 2009, based on community at district of Sleman-Yogyakarta. The covered subjects were 12073 over 17 years, after selected by aged of 30-59 years old, we get 7695 people and grouped in normotension, pre-hypertension and hypertension. Stratified randomize was done to select 51 for hypertension and 51 normotension involving this study. Genotypes based on the polymorphisms (II/ID/DD) using a polymerase chain reaction (PCR) methode, at Biochemistry Laboratory Faculty of Medicine Gadjah Mada University Yogyakarta. Results: The genotype frequencies in hypertensive group versus normal were II 23(45.0%) vs 37(72.5%), ID 25(49.0%) vs 13(25.5%) and DD 3(6.0%) vs 1(2.0%) p=0.043. The allele frequencies were I allele 35(68.5%) vs 43(84.5%), D allele 16(31.5%) vs 8(15.5%), p=0.038. Logistic regression analysis showed that D allele as a risk factor for hypertension. Conclusion: Frequencies of ID and DD genotypes and D allele ACE gene in hypertensive subject were higher than normotensive subjects. The D allele of the ACE gene was a predisposing factor in hypertension. [Yogyakarta] : Universitas Gadjah Mada 2011 Thesis NonPeerReviewed , SUTARSO KAMAJAYA and , Prof. Dr. dr. Moch. Sja'bani, M.Med.Sc., SpPD-KGH (2011) POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN (Tinjauan Pustaka dan Laporan Penelitian). UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=52051 |
| spellingShingle | ETD , SUTARSO KAMAJAYA , Prof. Dr. dr. Moch. Sja'bani, M.Med.Sc., SpPD-KGH POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN (Tinjauan Pustaka dan Laporan Penelitian) |
| title | POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN
(Tinjauan Pustaka dan Laporan Penelitian) |
| title_full | POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN
(Tinjauan Pustaka dan Laporan Penelitian) |
| title_fullStr | POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN
(Tinjauan Pustaka dan Laporan Penelitian) |
| title_full_unstemmed | POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN
(Tinjauan Pustaka dan Laporan Penelitian) |
| title_short | POLIMORFISME GEN ANGIOTENSIN I CONVERTING ENZYME (ACE) INSERSI/DELESI (I/D) DAN HEIPERTENSI PADA PENDUDUK MLATI SLEMAN
(Tinjauan Pustaka dan Laporan Penelitian) |
| title_sort | polimorfisme gen angiotensin i converting enzyme ace insersi delesi i d dan heipertensi pada penduduk mlati sleman tinjauan pustaka dan laporan penelitian |
| topic | ETD |
| work_keys_str_mv | AT sutarsokamajaya polimorfismegenangiotensiniconvertingenzymeaceinsersidelesiiddanheipertensipadapendudukmlatislemantinjauanpustakadanlaporanpenelitian AT profdrdrmochsjabanimmedscsppdkgh polimorfismegenangiotensiniconvertingenzymeaceinsersidelesiiddanheipertensipadapendudukmlatislemantinjauanpustakadanlaporanpenelitian |