| Summary: | Objective :To assess the effect of intravenous clonidine 3µg/kg on
prolongation of motoric and sensoric blockade in sub
arachnoid block with hyperbaric bupivacaine 0,5%.
Design : Randomized Double Blind Controlled Trial.
Setting : Patients indicated for SAB, undergo perineal, lower extremity,
urology, and lower gynecology elective surgery in Central
Operating Theatre of Dr.Sardjito Hospital Yogyakarta.
Subject : 60 subjects, men and women, ages between 16-65 years old,
the phyisical status ASA I-II, body weight 40-70 kg, height 150-
170 cm (BMI 17,5-24,5 kg/m
2
, procedure less than 120
minutes.
Intervention :Subject were divided into two groups. 30 subjects in each
group, 3 subjects dropout. Group A was given clonidine
3µg/kgBW in NaCl 100ml. Group B was given NaCl 100ml. All
interventions started 20 minutes after SAB and administered in
20 minutes. Local anesthesia for SAB was 0.5% hyperbaric
bupivacaine 15 mg.
Outcome measure : The main outcome measures were motoric blockade and
sensoric blockade duration. Hemodynamics and respiratory
parameters which were blood pressure, MAP, heart rate,
respiratory rate, and O2 saturation were also measured.
Results : Demographic data between two groups were comparable.
Sensoric blockade duration was prolonged in the clonidine
group compared to the control group i.e. 183.90 ± 29.29
minutes vs 162.70 ± 25.46 minutes, p=0.004 (p<0.05). Motoric
blockade duration was not prolonged in the clonidine group
compared to the control group i.e. 151.00 ± 23.80 minutes vs
145.00 ± 15.65 minutes, p=0.253 (p>0.05). Difference of blood
pressure, MAP, heart rate, respiratory rate, and O2 saturation
were not statistically significant.
Conclusion : Clonidine 3µg/kgBW intravenously prolonged the duration of
sensoric blockade in SAB with 0.5% hyperbaric bupivacaine,
but it didn�t prolong the duration of motoric blockade.
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