| Summary: | Background: Neonatal sepsis is still known as a leading cause of neonatal morbidity and mortality. It is hard to diagnose sepsis clinically due to no specific signs and symptoms. Confirmation of the diagnosis may take time, costly, and it is not easily performed in any hospital. There is an urgent need to know whether the baby has sepsis to institute treatment as quickly as possible, according to the Indonesian pediatrician society (IDAI) medical standards for diagnose sepsis clinically. Objective: to evaluate diagnostic accuracy of IDAI medical standards to diagnose neonatal sepsis based on blood culture result. Method: This study was a cross-sectional and carried out at the Perinatal ward of Maternal Perinatal Unit Dr. Sardjito Hospital Yogyakarta between June 1st, 2010 to November 31st, 2010. The inclusion criteria was neonate who admitted to Perinatololy ward and had symptom or sign of sepsis based on Sardjito medical standards. Neonates with congenital anomaly, blood disorder, or the mother took antibiotic intrapartum were excluded from this study. The neonates got diagnose from IDAI medical standards and further were blind validated with blood culture. Result: A total of 193 babies with signs of sepsis were evaluated. The clinical diagnosis was made based on IDAI medical standards (known as SPM IDAI). Leucocyte count, immature/total neutrophil ratio, and blood culture were performed in all subjects at enrollment. The outcome of interest was �definite sepsis�, defined as blood culture positive. The SPM IDAI had sensitivity, specificity, PPV, NPV, LR+, LR�, and accuracy of 88%, 17%, 53%, 57%, 1,06, 0,71, and 53% respectively. The �clinical sepsis� can be used by clinicians to diagnose sepsis at the beginning. Conclusion: SPM IDAI had high sensitivity for diagnose neonatal sepsis based on result of blood culture.
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