| Summary: | The defective induction of senescence may provoke keloid. Therapy that
induces fibroblasts senescence can be used to prevent the keloid. Triamcinolon
acetonide (TA) or Mitomycin C (MMC) can improve keloid by decreasing
fibroblasts proliferation that is also the characteristic of cellular senescence.
We investigated the effect of TA or MMC on SA-βgal senescence-marker
expression of keloid fibroblasts, the optimum dose of TA or MMC and the
potential difference in increasing the expression between the use of TA and
MMC.
Passage III keloid fibroblasts culture was divided into 8 groups of
treatment: placebo, 150 µM H2O2 (as procedure control), TA (10, 20, 40 µM), and
MMC (0,015
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