| Summary: | The venom of Viperidae may contains anti-angiogenesis proteins so that can be used
as cancer treatment therapy. Cancer�s growth greatly depends on angiogenesis, the
formation of new vessels from the existed vessels of the host toward the cancer
tissues. The blockage of angiogenesis process of the cancer�s tissues is cancer
therapy alternatives. White-lipped green pit viper is one of the Viperid that
abundantly can be found in Indonesia. This study is to know the effect of the snake
venom�s protein on breast cancer angiogenesis. In this study, protein fractions of the
ammonium sulphate concentration considerably 30% (FP30), 60% (FP60), and 100%
(FP100) saturation were used, each has dilution of 50x, 2500x, and 5000x. Antiangiogenesis
test was done by using Chorio-Allantoic Membrane (CAM) of chick
embryo that were implanted by the normal and breast cancer rat�s graft. Forty-five
chicken eggs day 10 were divided into four groups of control and eleven groups of
treatments, each had three replications. The study result showed that snake venom�s
protein FP60 may inhibit cancer angiogenesis.
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