| Summary: | Background. Hypertension is a major risk for development and progresivity
complication macrovascular and microvascular of diabetes mellitus. Reninangiotensin-
aldosteron system (RAAS), insulin resistance, endothelial dysfunction
and autonomic nervous dysfunction play an important part in the pathogenesis of
hypertension and type 2 diabetes mellitus. In RAAS, increased angiotensin II
constricts arterioles, raises total peripheral resistance and blood volume. The rise
in intravascular volume increases risk of hypertension. Glucotoxicity or
hyperglycemia in type 2 diabetes mellitus can increases angiotensin II levels.
Aim. To evaluate plasma angiotensin II levels in type 2 diabetes mellitus women
with or without hypertension.
Methods. Cross sectional design was conducted on subjects from outpatients
women with type 2 diabetes mellitus at endocrinology clinic, Dr. Sardjito General
Hospital, Yogyakarta. Hypertension was assessed using criteria from Seventh
Joint National Committee (2003). ELISA sandwich�s methods was used to
measure plasma angiotensin II levels from veins blood. Differences between
groups were compared by student�s unpaired t-test and Mann-Whitney test.
Results. Among 60 subjects, there are 30 with hypertension (50%) and 30 without
hypertension (50%). Mean age were 54,11 ± 3,36 years old. Plasma angiotensin II
levels seemed higher in type 2 diabetes mellitus women with hypertension than
without hypertension although they were not statistically significant (0,30 ± 0,15
ng/ml vs. 0,28 ± 0,18 ng/ml, p=0,93).
Conclusion. The plasma angiotensin II levels has no significant different between
type 2 diabetes mellitus women with or without hypertension.
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