| Summary: | Background. Most of squamous cell carcinoma (SCC) of the upper aerodigestive
tract are conventional type and as such, show to some degree a recapitulation of
stratified squamous epithelium. However, certain SCC of the upper aerodigestive
tract have different growth patterns and histologic features. Sinonasal
lymphoepithelial carcinoma (SNLEC) is a variant of SCC which is common in
nasopharynx but its primary lesion in sinonasal without lesion in nasopharynx and
associated strongly with Epstein-Barr Virus (EBV). Whereas sinonasal
undifferentiated carcinoma (SNUC) is distinctive tumor of the sinonasal tract and
lack of EBV RNA. SNLEC is common in a high incidence area of nasopharynx
carcinoma.
EBNA-1 detection with immunohistochemistry can replace detection method
for EBER, because EBNA-1 is expressed in all three of latent phase EBV infection.
LMP-1 is expressed by carcinomas which are related with EBV and has worse
prognosis. Malignant neoplasms of the sinonasal are difficult to be treated and related
with worse prognosis.
Objective. The purpose of this study was to observe the role of Epstein Barr Virus
infection as a risk factor for the incidence of carcinoma sinonasal.
Methods. This study implemented a case control with a chi square to analyze the
hypothesis. The procedure for this study initiated with collecting samples from biopsy
of carcinoma sinonasal patients and rhinosinusitis patients, afterwards samples from
both groups were stained with immunohistochemistry method to EBNA-1 and LMP-1
protein in the Anatomical Pathology Laboratory of Medical Faculty Gadjah Mada
University.
Results. The samples numbered 48 people, consisting of groups of cases, ie patients
with sinonasal tumors of squamous cell carcinoma from anatomic pathology as many
as 24 people and a control group, ie patients with chronic rhinosinusitis as many as 24
people. Found significant relation in protein expression of high LMP-1 (�30) and
low LMP-1 (<30) between the case group with controls with a P value: <0.001
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