UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL
<p>UK-2A is a novel antifungi from Streptomyces sp. 517-02, and its structure is similar to that of Antimycin A3. Antimycin A3 itself was found to induce apoptosis by inhibition of Bcl-xL, an anti-apoptotic enzyme in mitochondria.<br /> In our research, several open-chained analogues of...
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| Format: | Article |
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[Yogyakarta] : Fak. MIPA Universitas Gadjah Mada
2007
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| _version_ | 1797031376063561728 |
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| author | , AMJ Putra, M Hanafi, Y Anita |
| author_facet | , AMJ Putra, M Hanafi, Y Anita |
| author_sort | , AMJ Putra, M Hanafi, Y Anita |
| collection | UGM |
| description | <p>UK-2A is a novel antifungi from Streptomyces sp. 517-02, and its structure is similar to that of Antimycin A3. Antimycin A3 itself was found to induce apoptosis by inhibition of Bcl-xL, an anti-apoptotic enzyme in mitochondria.<br />
In our research, several open-chained analogues of UK-2A were virtually docked into Bcl-xL for structure-activity relationship studies. The dockings were performed by mean of ArgusLab 4.0.1 software. The enzyme was represented by 1ysg PDB file, downloaded from US RCSB website. Analogue with the lowest free binding energy (&Delta |
| first_indexed | 2024-03-13T22:20:49Z |
| format | Article |
| id | oai:generic.eprints.org:93930 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:20:49Z |
| publishDate | 2007 |
| publisher | [Yogyakarta] : Fak. MIPA Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:939302014-11-28T07:36:08Z https://repository.ugm.ac.id/93930/ UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL , AMJ Putra, M Hanafi, Y Anita <p>UK-2A is a novel antifungi from Streptomyces sp. 517-02, and its structure is similar to that of Antimycin A3. Antimycin A3 itself was found to induce apoptosis by inhibition of Bcl-xL, an anti-apoptotic enzyme in mitochondria.<br /> In our research, several open-chained analogues of UK-2A were virtually docked into Bcl-xL for structure-activity relationship studies. The dockings were performed by mean of ArgusLab 4.0.1 software. The enzyme was represented by 1ysg PDB file, downloaded from US RCSB website. Analogue with the lowest free binding energy (&Delta [Yogyakarta] : Fak. MIPA Universitas Gadjah Mada 2007 Article NonPeerReviewed , AMJ Putra, M Hanafi, Y Anita (2007) UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL. text. http://repository.ugm.ac.id/digitasi/index.php?module=cari_hasil_full&idbuku=1729 |
| spellingShingle | , AMJ Putra, M Hanafi, Y Anita UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL |
| title | UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL |
| title_full | UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL |
| title_fullStr | UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL |
| title_full_unstemmed | UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL |
| title_short | UK-2A ANALOGUES: POTENTIAL INHIBITORS OF BCL-XL |
| title_sort | uk 2a analogues potential inhibitors of bcl xl |
| work_keys_str_mv | AT amjputramhanafiyanita uk2aanaloguespotentialinhibitorsofbclxl |