| Summary: | <p>Ochratoxin A (OTA) is the most toxic of the ochratoxins. Ochratoxin A is structurally similar to the amino acid phenylalanine (Phe), it has an inhibitory effect on a number of enzymes that use Phe as a substrate. Its toxicity has been associated with inhibition of protein synthesis, DNA and RNA synthesis, mitochondrial dysfunction, formation of DNA adducts, disruption of calcium homeostasis, the generation of reactive oxygen species and stimulated lipid peroxidation. This experiment was performed to examine the effects of Ochratoxin A in pregnant mice at the organogenesis period on growth, development of embryos and foetuses, brain development and postnatal behavior of post weaning mice. This research was conducted in two stages, using 30 pregnant mice in each stage. Thirthty pregnant mice in each stage were divided randomly into 5 groups of 12. Ochratoxin A was dissolved in sodium bicarbonate and administrated orally on seventh to fourteenth days of gestation. Ochratoxin A was given at the dosage of 0,5
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