STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A
<p>Ochratoxin A (OTA) is the most toxic of the ochratoxins. Ochratoxin A is structurally similar to the amino acid phenylalanine (Phe), it has an inhibitory effect on a number of enzymes that use Phe as a substrate. Its toxicity has been associated with inhibition of protein synthesis, DNA and...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
[Yogyakarta] : Fakultas Biologi Universitas Gadjah Mada
2012
|
| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/95262/1/3090_RD12110009-arumsetiawan.pdf |
| _version_ | 1797031644468609024 |
|---|---|
| author | Setiawan, Arum |
| author_facet | Setiawan, Arum |
| author_sort | Setiawan, Arum |
| collection | UGM |
| description | <p>Ochratoxin A (OTA) is the most toxic of the ochratoxins. Ochratoxin A is structurally similar to the amino acid phenylalanine (Phe), it has an inhibitory effect on a number of enzymes that use Phe as a substrate. Its toxicity has been associated with inhibition of protein synthesis, DNA and RNA synthesis, mitochondrial dysfunction, formation of DNA adducts, disruption of calcium homeostasis, the generation of reactive oxygen species and stimulated lipid peroxidation. This experiment was performed to examine the effects of Ochratoxin A in pregnant mice at the organogenesis period on growth, development of embryos and foetuses, brain development and postnatal behavior of post weaning mice. This research was conducted in two stages, using 30 pregnant mice in each stage. Thirthty pregnant mice in each stage were divided randomly into 5 groups of 12. Ochratoxin A was dissolved in sodium bicarbonate and administrated orally on seventh to fourteenth days of gestation. Ochratoxin A was given at the dosage of 0,5 |
| first_indexed | 2024-03-13T22:25:15Z |
| format | Article |
| id | oai:generic.eprints.org:95262 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-13T22:25:15Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Fakultas Biologi Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:952622016-02-19T06:12:00Z https://repository.ugm.ac.id/95262/ STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A Setiawan, Arum Biological Sciences <p>Ochratoxin A (OTA) is the most toxic of the ochratoxins. Ochratoxin A is structurally similar to the amino acid phenylalanine (Phe), it has an inhibitory effect on a number of enzymes that use Phe as a substrate. Its toxicity has been associated with inhibition of protein synthesis, DNA and RNA synthesis, mitochondrial dysfunction, formation of DNA adducts, disruption of calcium homeostasis, the generation of reactive oxygen species and stimulated lipid peroxidation. This experiment was performed to examine the effects of Ochratoxin A in pregnant mice at the organogenesis period on growth, development of embryos and foetuses, brain development and postnatal behavior of post weaning mice. This research was conducted in two stages, using 30 pregnant mice in each stage. Thirthty pregnant mice in each stage were divided randomly into 5 groups of 12. Ochratoxin A was dissolved in sodium bicarbonate and administrated orally on seventh to fourteenth days of gestation. Ochratoxin A was given at the dosage of 0,5 [Yogyakarta] : Fakultas Biologi Universitas Gadjah Mada 2012 Article NonPeerReviewed application/pdf en https://repository.ugm.ac.id/95262/1/3090_RD12110009-arumsetiawan.pdf Setiawan, Arum (2012) STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A. Laporan Penelitian. (Submitted) https://repository.ugm.ac.id/digitasi/index.php?module=cari_hasil_full&idbuku=3090 |
| spellingShingle | Biological Sciences Setiawan, Arum STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A |
| title | STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A |
| title_full | STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A |
| title_fullStr | STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A |
| title_full_unstemmed | STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A |
| title_short | STUDY OF TERATOGENESIS, BRAIN DEVELOPMENT AND POSTNATAL BEHAVIOR OF FETAL MICE (Mus musculus L.) Swiss Webster INDUCED BY OCHRATOXIN A |
| title_sort | study of teratogenesis brain development and postnatal behavior of fetal mice mus musculus l swiss webster induced by ochratoxin a |
| topic | Biological Sciences |
| url | https://repository.ugm.ac.id/95262/1/3090_RD12110009-arumsetiawan.pdf |
| work_keys_str_mv | AT setiawanarum studyofteratogenesisbraindevelopmentandpostnatalbehavioroffetalmicemusmusculuslswisswebsterinducedbyochratoxina |