| Summary: | <p>Pukul empat (Mirabilisjalapa L.) is one of plant that has anticancer effect. Pukul empat leaves contains flavonoid active compound and it can inhibit the invasion of human oral tounge cancer. The aim of this study was to examine the potency of pukul empat (Mirabilis jalapa L.) leaves ethanolic extract toward invasion of human oral tounge cancer Supri's clone 1 (SP-C1). Research design in this study was pure laboratory experimental. This study was used a human oral tounge cancer cell SP-C1 that added pukul empat leaves ethanolic extract. Potency of pukul empat leaves ethanolic extract to invasion of human oral tounge cancer cell SP-C1 was evaluated by Boyden Chamber, Rosswell Park Memorial Institute 1640 (RPMI-1640)and FBS10% with some pukul empat leaves ethanolic extract (0, 7.5, 15, 25, 50, 75J.&mu
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