PENGARUH ASAM ASKORBAT ORAL TERHADAP KERUSAKAN SEL ENDOTEL KORNEA PADA FAKOEMULSIFIKASI
Phacoemulsification cataract surgery is ABSTRACT the most popular of cataract surgery technique that can damage corneal endothelial cell. Ascorbic acid can reduce corneal endothelial cell damage. The objective of this study was to compare the corneal endothelial cell loss due to phacoemulsification...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2012
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| author | , dr. Nika Bellarinatasari , dr. Tri Wahyu Widayanti, SpM, KVR, MKes, |
| author_facet | , dr. Nika Bellarinatasari , dr. Tri Wahyu Widayanti, SpM, KVR, MKes, |
| author_sort | , dr. Nika Bellarinatasari |
| collection | UGM |
| description | Phacoemulsification cataract surgery is
ABSTRACT
the most popular of cataract surgery
technique that can damage corneal endothelial cell. Ascorbic acid can reduce
corneal endothelial cell damage. The objective of this study was to compare the
corneal endothelial cell loss due to phacoemulsification surgery in ascorbic acid
group and placebo group This was a clinical study with double blinds randomized
controlled trial. There were 66 subjects enrolled, divided into 2 groups, ascorbic
acid group that was given 2 g orally with divided doses 500 mg four times at
night, morning, afternoon and 2 hours before surgery (n=32) and placebo group
(n=34). Endothelial cell counts were performed before and 7 days after
phacoemulsification surgery.
Administration of 2 g ascorbic acid in divided doses of 500 mg given 4 times
before phacoemulsification surgery caused less corneal endothelial cell loss
229,27 ± 191,58 cells/mm
2
(9,10% ± 6,88%) compared with the administration of
placebo had endothelial cell loss 364,64 ± 255,25 cells/mm
2
(14,85% ± 10,54%).
There are statistically significantly different in endothelial cell loss between the
two groups (p<0,05), but no clinically significantly different. The baseline
characteristic between the both groups was similar.
2 g In conclusion, administration of ascorbic acid in divided doses of 500 mg
given 4 times before phacoemulsification surgery can reduce the corneal
endothelial cell loss |
| first_indexed | 2024-03-13T22:32:57Z |
| format | Thesis |
| id | oai:generic.eprints.org:97472 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:32:57Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:974722016-03-04T08:49:41Z https://repository.ugm.ac.id/97472/ PENGARUH ASAM ASKORBAT ORAL TERHADAP KERUSAKAN SEL ENDOTEL KORNEA PADA FAKOEMULSIFIKASI , dr. Nika Bellarinatasari , dr. Tri Wahyu Widayanti, SpM, KVR, MKes, ETD Phacoemulsification cataract surgery is ABSTRACT the most popular of cataract surgery technique that can damage corneal endothelial cell. Ascorbic acid can reduce corneal endothelial cell damage. The objective of this study was to compare the corneal endothelial cell loss due to phacoemulsification surgery in ascorbic acid group and placebo group This was a clinical study with double blinds randomized controlled trial. There were 66 subjects enrolled, divided into 2 groups, ascorbic acid group that was given 2 g orally with divided doses 500 mg four times at night, morning, afternoon and 2 hours before surgery (n=32) and placebo group (n=34). Endothelial cell counts were performed before and 7 days after phacoemulsification surgery. Administration of 2 g ascorbic acid in divided doses of 500 mg given 4 times before phacoemulsification surgery caused less corneal endothelial cell loss 229,27 ± 191,58 cells/mm 2 (9,10% ± 6,88%) compared with the administration of placebo had endothelial cell loss 364,64 ± 255,25 cells/mm 2 (14,85% ± 10,54%). There are statistically significantly different in endothelial cell loss between the two groups (p<0,05), but no clinically significantly different. The baseline characteristic between the both groups was similar. 2 g In conclusion, administration of ascorbic acid in divided doses of 500 mg given 4 times before phacoemulsification surgery can reduce the corneal endothelial cell loss [Yogyakarta] : Universitas Gadjah Mada 2012 Thesis NonPeerReviewed , dr. Nika Bellarinatasari and , dr. Tri Wahyu Widayanti, SpM, KVR, MKes, (2012) PENGARUH ASAM ASKORBAT ORAL TERHADAP KERUSAKAN SEL ENDOTEL KORNEA PADA FAKOEMULSIFIKASI. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=54426 |
| spellingShingle | ETD , dr. Nika Bellarinatasari , dr. Tri Wahyu Widayanti, SpM, KVR, MKes, PENGARUH ASAM ASKORBAT ORAL TERHADAP KERUSAKAN SEL ENDOTEL KORNEA PADA FAKOEMULSIFIKASI |
| title | PENGARUH ASAM ASKORBAT ORAL TERHADAP
KERUSAKAN SEL ENDOTEL KORNEA PADA
FAKOEMULSIFIKASI |
| title_full | PENGARUH ASAM ASKORBAT ORAL TERHADAP
KERUSAKAN SEL ENDOTEL KORNEA PADA
FAKOEMULSIFIKASI |
| title_fullStr | PENGARUH ASAM ASKORBAT ORAL TERHADAP
KERUSAKAN SEL ENDOTEL KORNEA PADA
FAKOEMULSIFIKASI |
| title_full_unstemmed | PENGARUH ASAM ASKORBAT ORAL TERHADAP
KERUSAKAN SEL ENDOTEL KORNEA PADA
FAKOEMULSIFIKASI |
| title_short | PENGARUH ASAM ASKORBAT ORAL TERHADAP
KERUSAKAN SEL ENDOTEL KORNEA PADA
FAKOEMULSIFIKASI |
| title_sort | pengaruh asam askorbat oral terhadap kerusakan sel endotel kornea pada fakoemulsifikasi |
| topic | ETD |
| work_keys_str_mv | AT drnikabellarinatasari pengaruhasamaskorbatoralterhadapkerusakanselendotelkorneapadafakoemulsifikasi AT drtriwahyuwidayantispmkvrmkes pengaruhasamaskorbatoralterhadapkerusakanselendotelkorneapadafakoemulsifikasi |