| Summary: | Introduction : Endotracheal intubation are associated with cardiovascular
changes such as hypertension, tachycardia and dysrythemias. The aim of the
present study to compare the responses of blood pressure and heart rate in
endotracheael intubation of 800 mg gabapentin premedication with 0.2 mg per
oral clonidin.
Methods : Study design with double blind randomized controlled trial. The
study subjects who were scheduled elective surgery at the Central Building
Integrated Surgery (GBST) RS Dr. Sardjito Yogyakarta, which performed under
general anesthesia with endotracheal intubation. The research consisted fivety
patients divided into two groups consisting of 25 patients, according to to the
agents to be used that is the group A (n = 25) received gabapentin 800 mg and
group B (n = 25) received 0.2 mg clonidin 2 hours before the schedule surgery.
The result were assessed about blood pressure and heart rate 3 minutes before
induction as a base-line, after induction and after intubation at 1,3,5 and 10
minutes.
Result : There was no statistically difference between two groups in the blood
pressure responses to tracheal intubation (p <0.05). Heart rate responses was
statistically difference between two groups at 1 minute after intubation that was
group gabapentin 90.56 (11.362) beat/mnt compared clonidin 82.24 (11.991)
beat/mnt (p < 0.05) and 3 minutes after intubation that was group gabapentin
86.36 (11.489) beat/mnt compared clonidin 78.80 (10.828) beat/mnt (p < 0.05).
The blood pressure responses to tracheal intubation was group gabapentin more
stable then group clonidin and the heart rate responses to tracheal intubation was
group clonidin more stable then group gabapentin.
Conclusions : The present study demonstrated that the blood pressure responses
to tracheal intubation was more stable in 800 mg gabapentin premedication then
with 0.2 mg per oral clonidin, and the heart rate responses to tracheal intubation
was more stable in 0.2 mg clonidin premedication then with 800 mg per oral
gabapentin.
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